Search Results

Overview

Uniprot IDO75164
Protein NameLysine-specific demethylase 4A
Gene NameKDM4A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1012 TLDEELPKRVKSRLS
1033 FNEIFTEKEVKQEKK
251 LISPLMLKKYGIPFD
506 LVFSGSKKKSSSSLG
507 VFSGSKKKSSSSLGS
549 LTVHSYAKGDGRVTV
893 IPNLERAKGALQSIT

Function

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20' (PubMed:16603238, PubMed:26741168, PubMed:21768309). Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues (PubMed:16603238, PubMed:26741168, PubMed:21768309). Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238). Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3) (PubMed:19144645, PubMed:30156264). Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (PubMed:16024779)

Protein Sequence

10 MASESETLNP 20 SARIMTFYPT 30 MEEFRNFSRY 40 IAYIESQGAH 50 RAGLAKVVPP 60 KEWKPRASYD 70 DIDDLVIPAP 80 IQQLVTGQSG 90 LFTQYNIQKK 100 AMTVREFRKI 110 ANSDKYCTPR 120 YSEFEELERK 130 YWKNLTFNPP 140 IYGADVNGTL 150 YEKHVDEWNI 160 GRLRTILDLV 170 EKESGITIEG 180 VNTPYLYFGM 190 WKTSFAWHTE 200 DMDLYSINYL 210 HFGEPKSWYS 220 VPPEHGKRLE 230 RLAKGFFPGS 240 AQSCEAFLRH 250 KMTLISPLML 260 KKYGIPFDKV 270 TQEAGEFMIT 280 FPYGYHAGFN 290 HGFNCAESTN 300 FATRRWIEYG 310 KQAVLCSCRK 320 DMVKISMDVF 330 VRKFQPERYK 340 LWKAGKDNTV 350 IDHTLPTPEA 360 AEFLKESELP 370 PRAGNEEECP 380 EEDMEGVEDG 390 EEGDLKTSLA 400 KHRIGTKRHR 410 VCLEIPQEVS 420 QSELFPKEDL 430 SSEQYEMTEC 440 PAALAPVRPT 450 HSSVRQVEDG 460 LTFPDYSDST 470 EVKFEELKNV 480 KLEEEDEEEE 490 QAAAALDLSV 500 NPASVGGRLV 510 FSGSKKKSSS 520 SLGSGSSRDS 530 ISSDSETSEP 540 LSCRAQGQTG 550 VLTVHSYAKG 560 DGRVTVGEPC 570 TRKKGSAARS 580 FSERELAEVA 590 DEYMFSLEEN 600 KKSKGRRQPL 610 SKLPRHHPLV 620 LQECVSDDET 630 SEQLTPEEEA 640 EETEAWAKPL 650 SQLWQNRPPN 660 FEAEKEFNET 670 MAQQAPHCAV 680 CMIFQTYHQV 690 EFGGFNQNCG 700 NASDLAPQKQ 710 RTKPLIPEMC 720 FTSTGCSTDI 730 NLSTPYLEED 740 GTSILVSCKK 750 CSVRVHASCY 760 GVPPAKASED 770 WMCSRCSANA 780 LEEDCCLCSL 790 RGGALQRAND 800 DRWVHVSCAV 810 AILEARFVNI 820 AERSPVDVSK 830 IPLPRFKLKC 840 IFCKKRRKRT 850 AGCCVQCSHG 860 RCPTAFHVSC 870 AQAAGVMMQP 880 DDWPFVVFIT 890 CFRHKIPNLE 900 RAKGALQSIT 910 AGQKVISKHK 920 NGRFYQCEVV 930 RLTTETFYEV 940 NFDDGSFSDN 950 LYPEDIVSQD 960 CLQFGPPAEG 970 EVVQVRWTDG 980 QVYGAKFVAS 990 HPIQMYQVEF 1000 EDGSQLVVKR 1010 DDVYTLDEEL 1020 PKRVKSRLSV 1030 ASDMRFNEIF 1040 TEKEVKQEKK 1050 RQRVINSRYR 1060 EDYIEPALYR AIME

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005721 pericentric heterochromatin
Molecular Function GO:0032452 histone demethylase activity
Molecular Function GO:0051864 histone H3K36 demethylase activity
Molecular Function GO:0140681 histone H3K36me2/H3K36me3 demethylase activity
Molecular Function GO:0032454 histone H3K9 demethylase activity
Molecular Function GO:0140684 histone H3K9me2/H3K9me3 demethylase activity
Molecular Function GO:0140005 histone H4K20me2 reader activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0010468 regulation of gene expression

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.