Search Results

Overview

Uniprot ID	O75165
Protein Name	DnaJ homolog subfamily C member 13
Gene Name	DNAJC13
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
693	IAMDQYGKFNKVPEW
696	DQYGKFNKVPEWQRL
983	WYFGNADKERSGPYG

Function

Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates the dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499)

Protein Sequence

10 MNIIRENKDL 20 ACFYTTKHSW 30 RGKYKRVFSV 40 GTHAITTYNP 50 NTLEVTNQWP 60 YGDICSISPV 70 GKGQGTEFNL 80 TFRKGSGKKS 90 ETLKFSTEHR 100 TELLTEALRF 110 RTDFSEGKIT 120 GRRYNCYKHH 130 WSDSRKPVIL 140 EVTPGGFDQI 150 NPATNRVLCS 160 YDYRNIEGFV 170 DLSDYQGGFC 180 ILYGGFSRLH 190 LFASEQREEI 200 IKSAIDHAGN 210 YIGISLRIRK 220 EPLEFEQYLN 230 LRFGKYSTDE 240 SITSLAEFVV 250 QKISPRHSEP 260 VKRVLALTET 270 CLVERDPATY 280 NIATLKPLGE 290 VFALVCDSEN 300 PQLFTIEFIK 310 GQVRKYSSTE 320 RDSLLASLLD 330 GVRASGNRDV 340 CVKMTPTHKG 350 QRWGLLSMPV 360 DEEVESLHLR 370 FLATPPNGNF 380 ADAVFRFNAN 390 ISYSGVLHAV 400 TQDGLFSENK 410 EKLINNAITA 420 LLSQEGDVVA 430 SNAELESQFQ 440 AVRRLVASKA 450 GFLAFTQLPK 460 FRERLGVKVV 470 KALKRSNNGI 480 IHAAVDMLCA 490 LMCPMHDDYD 500 LRQEQLNKAS 510 LLSSKKFLEN 520 LLEKFNSHVD 530 HGTGALVISS 540 LLDFLTFALC 550 APYSETTEGQ 560 QFDMLLEMVA 570 SNGRTLFKLF 580 QHPSMAIIKG 590 AGLVMKAIIE 600 EGDKEIATKM 610 QELALSEGAL 620 PRHLHTAMFT 630 ISSDQRMLTN 640 RQLSRHLVGL 650 WTADNATATN 660 LLKRILPPGL 670 LAYLESSDLV 680 PEKDADRMHV 690 RDNVKIAMDQ 700 YGKFNKVPEW 710 QRLAGKAAKE 720 VEKFAKEKVD 730 LVLMHWRDRM 740 GIAQKENINQ 750 KPVVLRKRRQ 760 RIKIEANWDL 770 FYYRFGQDHA 780 RSNLIWNFKT 790 REELKDTLES 800 EMRAFNIDRE 810 LGSANVISWN 820 HHEFEVKYEC 830 LAEEIKIGDY 840 YLRLLLEEDE 850 NEESGSIKRS 860 YEFFNELYHR 870 FLLTPKVNMK 880 CLCLQALAIV 890 YGRCHEEIGP 900 FTDTRYIIGM 910 LERCTDKLER 920 DRLILFLNKL 930 ILNKKNVKDL 940 MDSNGIRILV 950 DLLTLAHLHV 960 SRATVPLQSN 970 VIEAAPDMKR 980 ESEKEWYFGN 990 ADKERSGPYG 1000 FHEMQELWTK 1010 GMLNAKTRCW 1020 AQGMDGWRPL 1030 QSIPQLKWCL 1040 LASGQAVLNE 1050 TDLATLILNM 1060 LITMCGYFPS 1070 RDQDNAIIRP 1080 LPKVKRLLSD 1090 STCLPHIIQL 1100 LLTFDPILVE 1110 KVAILLYHIM 1120 QDNPQLPRLY 1130 LSGVFFFIMM 1140 YTGSNVLPVA 1150 RFLKYTHTKQ 1160 AFKSEETKGQ 1170 DIFQRSILGH 1180 ILPEAMVCYL 1190 ENYEPEKFSE 1200 IFLGEFDTPE 1210 AIWSSEMRRL 1220 MIEKIAAHLA 1230 DFTPRLQSNT 1240 RALYQYCPIP 1250 IINYPQLENE 1260 LFCNIYYLKQ 1270 LCDTLRFPDW 1280 PIKDPVKLLK 1290 DTLDAWKKEV 1300 EKKPPMMSID 1310 DAYEVLNLPQ 1320 GQGPHDESKI 1330 RKAYFRLAQK 1340 YHPDKNPEGR 1350 DMFEKVNKAY 1360 EFLCTKSAKI 1370 VDGPDPENII 1380 LILKTQSILF 1390 NRHKEDLQPY 1400 KYAGYPMLIR 1410 TITMETSDDL 1420 LFSKESPLLP 1430 AATELAFHTV 1440 NCSALNAEEL 1450 RRENGLEVLQ 1460 EAFSRCVAVL 1470 TRASKPSDMS 1480 VQVCGYISKC 1490 YSVAAQFEEC 1500 REKITEMPSI 1510 IKDLCRVLYF 1520 GKSIPRVAAL 1530 GVECVSSFAV 1540 DFWLQTHLFQ 1550 AGILWYLLGF 1560 LFNYDYTLEE 1570 SGIQKSEETN 1580 QQEVANSLAK 1590 LSVHALSRLG 1600 GYLAEEQATP 1610 ENPTIRKSLA 1620 GMLTPYVARK 1630 LAVASVTEIL 1640 KMLNSNTESP 1650 YLIWNNSTRA 1660 ELLEFLESQQ 1670 ENMIKKGDCD 1680 KTYGSEFVYS 1690 DHAKELIVGE 1700 IFVRVYNEVP 1710 TFQLEVPKAF 1720 AASLLDYIGS 1730 QAQYLHTFMA 1740 ITHAAKVESE 1750 QHGDRLPRVE 1760 MALEALRNVI 1770 KYNPGSESEC 1780 IGHFKLIFSL 1790 LRVHGAGQVQ 1800 QLALEVVNIV 1810 TSNQDCVNNI 1820 AESMVLSSLL 1830 ALLHSLPSSR 1840 QLVLETLYAL 1850 TSSTKIIKEA 1860 MAKGALIYLL 1870 DMFCNSTHPQ 1880 VRAQTAELFA 1890 KMTADKLIGP 1900 KVRITLMKFL 1910 PSVFMDAMRD 1920 NPEAAVHIFE 1930 GTHENPELIW 1940 NDNSRDKVST 1950 TVREMMLEHF 1960 KNQQDNPEAN 1970 WKLPEDFAVV 1980 FGEAEGELAV 1990 GGVFLRIFIA 2000 QPAWVLRKPR 2010 EFLIALLEKL 2020 TELLEKNNPH 2030 GETLETLTMA 2040 TVCLFSAQPQ 2050 LADQVPPLGH 2060 LPKVIQAMNH 2070 RNNAIPKSAI 2080 RVIHALSENE 2090 LCVRAMASLE 2100 TIGPLMNGMK 2110 KRADTVGLAC 2120 EAINRMFQKE 2130 QSELVAQALK 2140 ADLVPYLLKL 2150 LEGIGLENLD 2160 SPAATKAQIV 2170 KALKAMTRSL 2180 QYGEQVNEIL 2190 CRSSVWSAFK 2200 DQKHDLFISE 2210 SQTAGYLTGP 2220 GVAGYLTAGT 2230 STSVMSNLPP 2240 PVDHEAGDLG YQT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0035577	azurophil granule membrane
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0030667	secretory granule membrane
Biological Process	GO:0007032	endosome organization
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0015031	protein transport
Biological Process	GO:0006898	receptor-mediated endocytosis
Biological Process	GO:2000641	regulation of early endosome to late endosome transport
Biological Process	GO:1902954	regulation of early endosome to recycling endosome transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.