Search Results

Overview

Uniprot IDO75175
Protein NameCCR4-NOT transcription complex subunit 3
Gene NameCNOT3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 TKTKAYSKEGLGLAQ
72 WVASNEIKDKRQLID
74 ASNEIKDKRQLIDNR

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity

Protein Sequence

10 MADKRKLQGE 20 IDRCLKKVSE 30 GVEQFEDIWQ 40 KLHNAANANQ 50 KEKYEADLKK 60 EIKKLQRLRD 70 QIKTWVASNE 80 IKDKRQLIDN 90 RKLIETQMER 100 FKVVERETKT 110 KAYSKEGLGL 120 AQKVDPAQKE 130 KEEVGQWLTN 140 TIDTLNMQVD 150 QFESEVESLS 160 VQTRKKKGDK 170 DKQDRIEGLK 180 RHIEKHRYHV 190 RMLETILRML 200 DNDSILVDAI 210 RKIKDDVEYY 220 VDSSQDPDFE 230 ENEFLYDDLD 240 LEDIPQALVA 250 TSPPSHSHME 260 DEIFNQSSST 270 PTSTTSSSPI 280 PPSPANCTTE 290 NSEDDKKRGR 300 STDSEVSQSP 310 AKNGSKPVHS 320 NQHPQSPAVP 330 PTYPSGPPPA 340 ASALSTTPGN 350 NGVPAPAAPP 360 SALGPKASPA 370 PSHNSGTPAP 380 YAQAVAPPAP 390 SGPSTTQPRP 400 PSVQPSGGGG 410 GGSGGGGSSS 420 SSNSSAGGGA 430 GKQNGATSYS 440 SVVADSPAEV 450 ALSSSGGNNA 460 SSQALGPPSG 470 PHNPPPSTSK 480 EPSAAAPTGA 490 GGVAPGSGNN 500 SGGPSLLVPL 510 PVNPPSSPTP 520 SFSDAKAAGA 530 LLNGPPQFST 540 APEIKAPEPL 550 SSLKSMAERA 560 AISSGIEDPV 570 PTLHLTERDI 580 ILSSTSAPPA 590 SAQPPLQLSE 600 VNIPLSLGVC 610 PLGPVPLTKE 620 QLYQQAMEEA 630 AWHHMPHPSD 640 SERIRQYLPR 650 NPCPTPPYHH 660 QMPPPHSDTV 670 EFYQRLSTET 680 LFFIFYYLEG 690 TKAQYLAAKA 700 LKKQSWRFHT 710 KYMMWFQRHE 720 EPKTITDEFE 730 QGTYIYFDYE 740 KWGQRKKEGF 750 TFEYRYLEDR DLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030014 CCR4-NOT complex
Cellular Component GO:0030015 CCR4-NOT core complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:2000036 regulation of stem cell population maintenance
Biological Process GO:0006417 regulation of translation
Biological Process GO:0031047 regulatory ncRNA-mediated gene silencing
Biological Process GO:0001829 trophectodermal cell differentiation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.