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Overview

Uniprot ID	O75177
Protein Name	Calcium-responsive transactivator
Gene Name	SS18L1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
13	ASARPRGKGEVTQQT

Function

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity)

Protein Sequence

10 MSVAFASARP 20 RGKGEVTQQT 30 IQKMLDENHH 40 LIQCILEYQS 50 KGKTAECTQY 60 QQILHRNLVY 70 LATIADSNQN 80 MQSLLPAPPT 90 QNMNLGPGAL 100 TQSGSSQGLH 110 SQGSLSDAIS 120 TGLPPSSLLQ 130 GQIGNGPSHV 140 SMQQTAPNTL 150 PTTSMSISGP 160 GYSHAGPASQ 170 GVPMQGQGTI 180 GNYVSRTNIN 190 MQSNPVSMMQ 200 QQAATSHYSS 210 AQGGSQHYQG 220 QSSIAMMGQG 230 SQGSSMMGQR 240 PMAPYRPSQQ 250 GSSQQYLGQE 260 EYYGEQYSHS 270 QGAAEPMGQQ 280 YYPDGHGDYA 290 YQQSSYTEQS 300 YDRSFEESTQ 310 HYYEGGNSQY 320 SQQQAGYQQG 330 AAQQQTYSQQ 340 QYPSQQSYPG 350 QQQGYGSAQG 360 APSQYPGYQQ 370 GQGQQYGSYR 380 APQTAPSAQQ 390 QRPYGYEQGQ YGNYQQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0071565	nBAF complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.