Search Results

Overview

Uniprot IDO75179
Protein NameAnkyrin repeat domain-containing protein 17
Gene NameANKRD17
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
63 RVCDLLLKKKPPQQQ
64 VCDLLLKKKPPQQQH

Function

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity)

Protein Sequence

10 MEKATVPVAA 20 ATAAEGEGSP 30 PAVAAVAGPP 40 AAAEVGGGVG 50 GSSRARSASS 60 PRGMVRVCDL 70 LLKKKPPQQQ 80 HHKAKRNRTC 90 RPPSSSESSS 100 DSDNSGGGGG 110 GGGGGGGGGG 120 TSSNNSEEEE 130 DDDDEEEEVS 140 EVESFILDQD 150 DLENPMLETA 160 SKLLLSGTAD 170 GADLRTVDPE 180 TQARLEALLE 190 AAGIGKLSTA 200 DGKAFADPEV 210 LRRLTSSVSC 220 ALDEAAAALT 230 RMRAESTANA 240 GQSDNRSLAE 250 ACSEGDVNAV 260 RKLLIEGRSV 270 NEHTEEGESL 280 LCLACSAGYY 290 ELAQVLLAMH 300 ANVEDRGIKG 310 DITPLMAAAN 320 GGHVKIVKLL 330 LAHKADVNAQ 340 SSTGNTALTY 350 ACAGGYVDVV 360 KVLLESGASI 370 EDHNENGHTP 380 LMEAGSAGHV 390 EVARLLLENG 400 AGINTHSNEF 410 KESALTLACY 420 KGHLEMVRFL 430 LEAGADQEHK 440 TDEMHTALME 450 ACMDGHVEVA 460 RLLLDSGAQV 470 NMPADSFESP 480 LTLAACGGHV 490 ELAALLIERG 500 ASLEEVNDEG 510 YTPLMEAARE 520 GHEEMVALLL 530 GQGANINAQT 540 EETQETALTL 550 ACCGGFLEVA 560 DFLIKAGADI 570 ELGCSTPLME 580 AAQEGHLELV 590 KYLLAAGANV 600 HATTATGDTA 610 LTYACENGHT 620 DVADVLLQAG 630 ADLEHESEGG 640 RTPLMKAARA 650 GHVCTVQFLI 660 SKGANVNRTT 670 ANNDHTVLSL 680 ACAGGHLAVV 690 ELLLAHGADP 700 THRLKDGSTM 710 LIEAAKGGHT 720 SVVCYLLDYP 730 NNLLSAPPPD 740 VTQLTPPSHD 750 LNRAPRVPVQ 760 ALPMVVPPQE 770 PDKPPANVAT 780 TLPIRNKAAS 790 KQKSSSHLPA 800 NSQDVQGYIT 810 NQSPESIVEE 820 AQGKLTELEQ 830 RIKEAIEKNA 840 QLQSLELAHA 850 DQLTKEKIEE 860 LNKTREEQIQ 870 KKQKILEELQ 880 KVERELQLKT 890 QQQLKKQYLE 900 VKAQRIQLQQ 910 QQQQSCQHLG 920 LLTPVGVGEQ 930 LSEGDYARLQ 940 QVDPVLLKDE 950 PQQTAAQMGF 960 APIQPLAMPQ 970 ALPLAAGPLP 980 PGSIANLTEL 990 QGVIVGQPVL 1000 GQAQLAGLGQ 1010 GILTETQQGL 1020 MVASPAQTLN 1030 DTLDDIMAAV 1040 SGRASAMSNT 1050 PTHSIAASIS 1060 QPQTPTPSPI 1070 ISPSAMLPIY 1080 PAIDIDAQTE 1090 SNHDTALTLA 1100 CAGGHEELVQ 1110 TLLERGASIE 1120 HRDKKGFTPL 1130 ILAATAGHVG 1140 VVEILLDNGA 1150 DIEAQSERTK 1160 DTPLSLACSG 1170 GRQEVVELLL 1180 ARGANKEHRN 1190 VSDYTPLSLA 1200 ASGGYVNIIK 1210 ILLNAGAEIN 1220 SRTGSKLGIS 1230 PLMLAAMNGH 1240 TAAVKLLLDM 1250 GSDINAQIET 1260 NRNTALTLAC 1270 FQGRTEVVSL 1280 LLDRKANVEH 1290 RAKTGLTPLM 1300 EAASGGYAEV 1310 GRVLLDKGAD 1320 VNAPPVPSSR 1330 DTALTIAADK 1340 GHYKFCELLI 1350 GRGAHIDVRN 1360 KKGNTPLWLA 1370 ANGGHLDVVQ 1380 LLVQAGADVD 1390 AADNRKITPL 1400 MAAFRKGHVK 1410 VVRYLVKEVN 1420 QFPSDSECMR 1430 YIATITDKEM 1440 LKKCHLCMES 1450 IVQAKDRQAA 1460 EANKNASILL 1470 EELDLEKLRE 1480 ESRRLALAAK 1490 REKRKEKRRK 1500 KKEEQRRKLE 1510 EIEAKNKENF 1520 ELQAAQEKEK 1530 LKVEDEPEVL 1540 TEPPSATTTT 1550 TIGISATWTT 1560 LAGSHGKRNN 1570 TITTTSSKRK 1580 NRKNKITPEN 1590 VQIIFDDPLP 1600 ISYSQPEKVN 1610 GESKSSSTSE 1620 SGDSDNMRIS 1630 SCSDESSNSN 1640 SSRKSDNHSP 1650 AVVTTTVSSK 1660 KQPSVLVTFP 1670 KEERKSVSGK 1680 ASIKLSETIS 1690 EGTSNSLSTC 1700 TKSGPSPLSS 1710 PNGKLTVASP 1720 KRGQKREEGW 1730 KEVVRRSKKV 1740 SVPSTVISRV 1750 IGRGGCNINA 1760 IREFTGAHID 1770 IDKQKDKTGD 1780 RIITIRGGTE 1790 STRQATQLIN 1800 ALIKDPDKEI 1810 DELIPKNRLK 1820 SSSANSKIGS 1830 SAPTTTAANT 1840 SLMGIKMTTV 1850 ALSSTSQTAT 1860 ALTVPAISSA 1870 STHKTIKNPV 1880 NNVRPGFPVS 1890 LPLAYPPPQF 1900 AHALLAAQTF 1910 QQIRPPRLPM 1920 THFGGTFPPA 1930 QSTWGPFPVR 1940 PLSPARATNS 1950 PKPHMVPRHS 1960 NQNSSGSQVN 1970 SAGSLTSSPT 1980 TTTSSSASTV 1990 PGTSTNGSPS 2000 SPSVRRQLFV 2010 TVVKTSNATT 2020 TTVTTTASNN 2030 NTAPTNATYP 2040 MPTAKEHYPV 2050 SSPSSPSPPA 2060 QPGGVSRNSP 2070 LDCGSASPNK 2080 VASSSEQEAG 2090 SPPVVETTNT 2100 RPPNSSSSSG 2110 SSSAHSNQQQ 2120 PPGSVSQEPR 2130 PPLQQSQVPP 2140 PEVRMTVPPL 2150 ATSSAPVAVP 2160 STAPVTYPMP 2170 QTPMGCPQPT 2180 PKMETPAIRP 2190 PPHGTTAPHK 2200 NSASVQNSSV 2210 AVLSVNHIKR 2220 PHSVPSSVQL 2230 PSTLSTQSAC 2240 QNSVHPANKP 2250 IAPNFSAPLP 2260 FGPFSTLFEN 2270 SPTSAHAFWG 2280 GSVVSSQSTP 2290 ESMLSGKSSY 2300 LPNSDPLHQS 2310 DTSKAPGFRP 2320 PLQRPAPSPS 2330 GIVNMDSPYG 2340 SVTPSSTHLG 2350 NFASNISGGQ 2360 MYGPGAPLGG 2370 APAAANFNRQ 2380 HFSPLSLLTP 2390 CSSASNDSSA 2400 QSVSSGVRAP 2410 SPAPSSVPLG 2420 SEKPSNVSQD 2430 RKVPVPIGTE 2440 RSARIRQTGT 2450 SAPSVIGSNL 2460 STSVGHSGIW 2470 SFEGIGGNQD 2480 KVDWCNPGMG 2490 NPMIHRPMSD 2500 PGVFSQHQAM 2510 ERDSTGIVTP 2520 SGTFHQHVPA 2530 GYMDFPKVGG 2540 MPFSVYGNAM 2550 IPPVAPIPDG 2560 AGGPIFNGPH 2570 AADPSWNSLI 2580 KMVSSSTENN 2590 GPQTVWTGPW 2600 APHMNSVHMN QLG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0045087 innate immune response
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Biological Process GO:1900245 positive regulation of MDA-5 signaling pathway
Biological Process GO:1900246 positive regulation of RIG-I signaling pathway
Biological Process GO:0006275 regulation of DNA replication

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.