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Overview

Uniprot IDO75182
Protein NamePaired amphipathic helix protein Sin3b
Gene NameSIN3B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1059 CDVDCRFKLSTHKMV
292 KMKLRGTKDLSIAAV
319 DKVRRVLKSQEVYEN
395 EIDYASCKRIGSSYR
406 SSYRALPKTYQQPKC
412 PKTYQQPKCSGRTAI
622 DTKALRSKSLLNEIE

Function

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482)

Protein Sequence

10 MAHAGGGSGG 20 SGAGGPAGRG 30 LSGARWGRSG 40 SAGHEKLPVH 50 VEDALTYLDQ 60 VKIRFGSDPA 70 TYNGFLEIMK 80 EFKSQSIDTP 90 GVIRRVSQLF 100 HEHPDLIVGF 110 NAFLPLGYRI 120 DIPKNGKLNI 130 QSPLTSQENS 140 HNHGDGAEDF 150 KQQVPYKEDK 160 PQVPLESDSV 170 EFNNAISYVN 180 KIKTRFLDHP 190 EIYRSFLEIL 200 HTYQKEQLNT 210 RGRPFRGMSE 220 EEVFTEVANL 230 FRGQEDLLSE 240 FGQFLPEAKR 250 SLFTGNGPCE 260 MHSVQKNEHD 270 KTPEHSRKRS 280 RPSLLRPVSA 290 PAKKKMKLRG 300 TKDLSIAAVG 310 KYGTLQEFSF 320 FDKVRRVLKS 330 QEVYENFLRC 340 IALFNQELVS 350 GSELLQLVSP 360 FLGKFPELFA 370 QFKSFLGVKE 380 LSFAPPMSDR 390 SGDGISREID 400 YASCKRIGSS 410 YRALPKTYQQ 420 PKCSGRTAIC 430 KELDHWTLLQ 440 GSWTDDYCMS 450 KFKNTCWIPG 460 YSAGVLNDTW 470 VSFPSWSEDS 480 TFVSSKKTPY 490 EEQLHRCEDE 500 RFELDVVLET 510 NLATIRVLES 520 VQKKLSRMAP 530 EDQEKFRLDD 540 SLGGTSEVIQ 550 RRAIYRIYGD 560 KAPEIIESLK 570 KNPVTAVPVV 580 LKRLKAKEEE 590 WREAQQGFNK 600 IWREQYEKAY 610 LKSLDHQAVN 620 FKQNDTKALR 630 SKSLLNEIES 640 VYDEHQEQHS 650 EGRSAPSSEP 660 HLIFVYEDRQ 670 ILEDAAALIS 680 YYVKRQPAIQ 690 KEDQGTIHQL 700 LHQFVPSLFF 710 SQQLDLGASE 720 ESADEDRDSP 730 QGQTTDPSER 740 KKPAPGPHSS 750 PPEEKGAFGD 760 APATEQPPLP 770 PPAPHKPLDD 780 VYSLFFANNN 790 WYFFLRLHQT 800 LCSRLLKIYR 810 QAQKQLLEYR 820 TEKEREKLLC 830 EGRREKGSDP 840 AMELRLKQPS 850 EVELEEYYPA 860 FLDMVRSLLE 870 GSIDPTQYED 880 TLREMFTIHA 890 YVGFTMDKLV 900 QNIARQLHHL 910 VSDDVCLKVV 920 ELYLNEKKRG 930 AAGGNLSSRC 940 VRAARETSYQ 950 WKAERCMADE 960 NCFKVMFLQR 970 KGQVIMTIEL 980 LDTEEAQTED 990 PVEVQHLARY 1000 VEQYVGTEGA 1010 SSSPTEGFLL 1020 KPVFLQRNLK 1030 KFRRRWQSEQ 1040 ARALRGEARS 1050 SWKRLVGVES 1060 ACDVDCRFKL 1070 STHKMVFIVN 1080 SEDYMYRRGT 1090 LCRAKQVQPL 1100 VLLRHHQHFE 1110 EWHSRWLEDN 1120 VTVEAASLVQ 1130 DWLMGEEDED 1140 MVPCKTLCET 1150 VHVHGLPVTR 1160 YRVQYSRRPA SP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030849 autosome
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0070822 Sin3-type complex
Cellular Component GO:0000805 X chromosome
Cellular Component GO:0001741 XY body
Cellular Component GO:0000806 Y chromosome
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0060633 negative regulation of transcription initiation by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.