Search Results
Overview
| Uniprot ID | O75190 |
|---|---|
| Protein Name | DnaJ homolog subfamily B member 6 |
| Gene Name | DNAJB6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | KSISTSTKMVNGRKI |
Function
Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048)
Protein Sequence
10
MVDYYEVLGV
20
QRHASPEDIK
30
KAYRKLALKW
40
HPDKNPENKE
50
EAERKFKQVA
60
EAYEVLSDAK
70
KRDIYDKYGK
80
EGLNGGGGGG
90
SHFDSPFEFG
100
FTFRNPDDVF
110
REFFGGRDPF
120
SFDFFEDPFE
130
DFFGNRRGPR
140
GSRSRGTGSF
150
FSAFSGFPSF
160
GSGFSSFDTG
170
FTSFGSLGHG
180
GLTSFSSTSF
190
GGSGMGNFKS
200
ISTSTKMVNG
210
RKITTKRIVE
220
NGQERVEVEE
230
DGQLKSLTIN
240
GVADDDALAE
250
ERMRRGQNAL
260
PAQPAGLRPP
270
KPPRPASLLR
280
HAPHCLSEEE
290
GEQDRPRAPG
300
PWDPLASAAG
310
LKEGGKRKKQ
320
KQREESKKKK
STKGNH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0090084 | negative regulation of inclusion body assembly |
| Biological Process | GO:0050877 | nervous system process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:1900034 | regulation of cellular response to heat |
| Biological Process | GO:0032880 | regulation of protein localization |
Reference
PMID: N/A