Search Results
Overview
| Uniprot ID | O75208 |
|---|---|
| Protein Name | Ubiquinone biosynthesis protein COQ9, mitochondrial |
| Gene Name | COQ9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | VQLGQAEKRKTDQFL |
| 288 | MNMGHTAKQVKSTGE |
Function
Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step (PubMed:25339443, PubMed:30661980, PubMed:38425362). Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25339443, PubMed:30661980)
Protein Sequence
10
MAAAAVSGAL
20
GRAGWRLLQL
30
RCLPVARCRQ
40
ALVPRAFHAS
50
AVGLRSSDEQ
60
KQQPPNSFSQ
70
QHSETQGAEK
80
PDPESSHSPP
90
RYTDQGGEEE
100
EDYESEEQLQ
110
HRILTAALEF
120
VPAHGWTAEA
130
IAEGAQSLGL
140
SSAAASMFGK
150
DGSELILHFV
160
TQCNTRLTRV
170
LEEEQKLVQL
180
GQAEKRKTDQ
190
FLRDAVETRL
200
RMLIPYIEHW
210
PRALSILMLP
220
HNIPSSLSLL
230
TSMVDDMWHY
240
AGDQSTDFNW
250
YTRRAMLAAI
260
YNTTELVMMQ
270
DSSPDFEDTW
280
RFLENRVNDA
290
MNMGHTAKQV
300
KSTGEALVQG
310
LMGAAVTLKN
LTGLNQRR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0019840 | isoprenoid binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006744 | ubiquinone biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.