Search Results
Overview
| Uniprot ID | O75223 |
|---|---|
| Protein Name | Gamma-glutamylcyclotransferase |
| Gene Name | GGCT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | KVATQEGKEITCRSY |
| 161 | LEYQEKLKAIEPNDY |
Function
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912)
Protein Sequence
10
MANSGCKDVT
20
GPDEESFLYF
30
AYGSNLLTER
40
IHLRNPSAAF
50
FCVARLQDFK
60
LDFGNSQGKT
70
SQTWHGGIAT
80
IFQSPGDEVW
90
GVVWKMNKSN
100
LNSLDEQEGV
110
KSGMYVVIEV
120
KVATQEGKEI
130
TCRSYLMTNY
140
ESAPPSPQYK
150
KIICMGAKEN
160
GLPLEYQEKL
170
KAIEPNDYTG
180
KVSEEIEDII
KKGETQTL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0003839 | gamma-glutamylcyclotransferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0001836 | release of cytochrome c from mitochondria |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.