Overview
| Uniprot ID | O75310 |
|---|
| Protein Name | UDP-glucuronosyltransferase 2B11 |
|---|
| Gene Name | UGT2B11 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 444 |
LYKENIMKLSRIQHD |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Exhibits narrow substrate specificity and very low catalytic activity compared to other UGT2B subfamily members (PubMed:8333863, PubMed:9169006, PubMed:9675083). Preferentially glucuronidates catechol estrogens. Also conjugates estriol and 3alpha-hydroxysteroids with activities 30-90 fold lower than UGT2B7. Shows no activity toward testosterone, hyodeoxycholic acid or most drugs. Physiological role remains unclear due to limited substrate range and low catalytic efficiency (PubMed:9675083)
Protein Sequence
10
MTLKWTSVLL
20
LIHLSCYFSS
30
GSCGKVLVWA
40
AEYSHWMNMK
50
TILKELVQRG
60
HEVTVLASSA
70
SILFDPNDAS
80
TLKFEVYPTS
90
LTKTEFENII
100
MQQVKRWSDI
110
RKDSFWLYFS
120
QEQEILWELY
130
DIFRNFCKDV
140
VSNKKVMKKL
150
QESRFDIVFA
160
DAVFPCGELL
170
AALLNIRFVY
180
SLRFTPGYTI
190
ERHSGGLIFP
200
PSYIPIVMSK
210
LSDQMTFMER
220
VKNMIYVLYF
230
DFWFQMSDMK
240
KWDQFYSEVL
250
GRPTTLFETM
260
GKADIWLMRN
270
SWSFQFPHPF
280
LPNVDFVGGF
290
HCKPAKPLPK
300
EMEEFVQSSG
310
ENGVVVFSLG
320
SVISNMTAER
330
ANVIATALAK
340
IPQKVLWRFD
350
GNKPDALGLN
360
TRLYKWIPQN
370
DLLGHPKTRA
380
FITHGGANGI
390
YEAIYHGIPM
400
VGIPLFFDQP
410
DNIAHMKAKG
420
AAVRLDFNTM
430
SSTDLLNALK
440
TVINDPLYKE
450
NIMKLSRIQH
460
DQPVKPLDRA
470
VFWIEFVMPH
480
KGAKHLRVAA
490
HDLTWFQYHS
500
LDVIGFLLAC
510
VATVIFIITK
520
FCLFCFWKFA
RKGKKGKRD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.