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Overview

Uniprot IDO75323
Protein NameProtein NipSnap homolog 2
Gene NameNIPSNAP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
148 MNKLRENKEFLEFRK
281 SRIMIPLKTSPLQ**
58 VRKVDPRKDAHSNLL
68 HSNLLAKKETSNLYK
75 KETSNLYKLQFHNVK
91 ECLEAYNKICQEVLP

Function

Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665)

Protein Sequence

10 MAARVLRARG 20 AAWAGGLLQR 30 AAPCSLLPRL 40 RTWTSSSNRS 50 REDSWLKSLF 60 VRKVDPRKDA 70 HSNLLAKKET 80 SNLYKLQFHN 90 VKPECLEAYN 100 KICQEVLPKI 110 HEDKHYPCTL 120 VGTWNTWYGE 130 QDQAVHLWRY 140 EGGYPALTEV 150 MNKLRENKEF 160 LEFRKARSDM 170 LLSRKNQLLL 180 EFSFWNEPVP 190 RSGPNIYELR 200 SYQLRPGTMI 210 EWGNYWARAI 220 RFRQDGNEAV 230 GGFFSQIGQL 240 YMVHHLWAYR 250 DLQTREDIRN 260 AAWHKHGWEE 270 LVYYTVPLIQ 280 EMESRIMIPL KTSPLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0000423 mitophagy
Biological Process GO:1901843 positive regulation of high voltage-gated calcium channel activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.