Search Results

Overview

Uniprot IDO75339
Protein NameCartilage intermediate layer protein 1
Gene NameCILP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1088 DQDPRTAKEIALGRC
871 HEDPRVKKTAFQISM
959 RACYIKVKIVGPLEV

Function

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage

Protein Sequence

10 MVGTKAWVFS 20 FLVLEVTSVL 30 GRQTMLTQSV 40 RRVQPGKKNP 50 SIFAKPADTL 60 ESPGEWTTWF 70 NIDYPGGKGD 80 YERLDAIRFY 90 YGDRVCARPL 100 RLEARTTDWT 110 PAGSTGQVVH 120 GSPREGFWCL 130 NREQRPGQNC 140 SNYTVRFLCP 150 PGSLRRDTER 160 IWSPWSPWSK 170 CSAACGQTGV 180 QTRTRICLAE 190 MVSLCSEASE 200 EGQHCMGQDC 210 TACDLTCPMG 220 QVNADCDACM 230 CQDFMLHGAV 240 SLPGGAPASG 250 AAIYLLTKTP 260 KLLTQTDSDG 270 RFRIPGLCPD 280 GKSILKITKV 290 KFAPIVLTMP 300 KTSLKAATIK 310 AEFVRAETPY 320 MVMNPETKAR 330 RAGQSVSLCC 340 KATGKPRPDK 350 YFWYHNDTLL 360 DPSLYKHESK 370 LVLRKLQQHQ 380 AGEYFCKAQS 390 DAGAVKSKVA 400 QLIVIASDET 410 PCNPVPESYL 420 IRLPHDCFQN 430 ATNSFYYDVG 440 RCPVKTCAGQ 450 QDNGIRCRDA 460 VQNCCGISKT 470 EEREIQCSGY 480 TLPTKVAKEC 490 SCQRCTETRS 500 IVRGRVSAAD 510 NGEPMRFGHV 520 YMGNSRVSMT 530 GYKGTFTLHV 540 PQDTERLVLT 550 FVDRLQKFVN 560 TTKVLPFNKK 570 GSAVFHEIKM 580 LRRKKPITLE 590 AMETNIIPLG 600 EVVGEDPMAE 610 LEIPSRSFYR 620 QNGEPYIGKV 630 KASVTFLDPR 640 NISTATAAQT 650 DLNFINDEGD 660 TFPLRTYGMF 670 SVDFRDEVTS 680 EPLNAGKVKV 690 HLDSTQVKMP 700 EHISTVKLWS 710 LNPDTGLWEE 720 EGDFKFENQR 730 RNKREDRTFL 740 VGNLEIRERR 750 LFNLDVPESR 760 RCFVKVRAYR 770 SERFLPSEQI 780 QGVVISVINL 790 EPRTGFLSNP 800 RAWGRFDSVI 810 TGPNGACVPA 820 FCDDQSPDAY 830 SAYVLASLAG 840 EELQAVESSP 850 KFNPNAIGVP 860 QPYLNKLNYR 870 RTDHEDPRVK 880 KTAFQISMAK 890 PRPNSAEESN 900 GPIYAFENLR 910 ACEEAPPSAA 920 HFRFYQIEGD 930 RYDYNTVPFN 940 EDDPMSWTED 950 YLAWWPKPME 960 FRACYIKVKI 970 VGPLEVNVRS 980 RNMGGTHRQT 990 VGKLYGIRDV 1000 RSTRDRDQPN 1010 VSAACLEFKC 1020 SGMLYDQDRV 1030 DRTLVKVIPQ 1040 GSCRRASVNP 1050 MLHEYLVNHL 1060 PLAVNNDTSE 1070 YTMLAPLDPL 1080 GHNYGIYTVT 1090 DQDPRTAKEI 1100 ALGRCFDGTS 1110 DGSSRIMKSN 1120 VGVALTFNCV 1130 ERQVGRQSAF 1140 QYLQSTPAQS 1150 PAAGTVQGRV 1160 PSRRQQRASR 1170 GGQRQGGVVA 1180 SLRFPRVAQQ PLIN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005615 extracellular space
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
Biological Process GO:0060392 negative regulation of SMAD protein signal transduction
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.