Search Results

Overview

Uniprot ID	O75347
Protein Name	Tubulin-specific chaperone A
Gene Name	TBCA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
51	DGENYDIKKQAEILQ
52	GENYDIKKQAEILQE

Function

Tubulin-folding protein; involved in the early step of the tubulin folding pathway

Protein Sequence

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0015630	microtubule cytoskeleton
Molecular Function	GO:0048487	beta-tubulin binding
Molecular Function	GO:0051087	protein-folding chaperone binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0015631	tubulin binding
Biological Process	GO:0007023	post-chaperonin tubulin folding pathway
Biological Process	GO:0006457	protein folding
Biological Process	GO:0007021	tubulin complex assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.