Search Results
Overview
| Uniprot ID | O75351 |
|---|---|
| Protein Name | Vacuolar protein sorting-associated protein 4B |
| Gene Name | VPS4B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | FPHLFTGKRTPWRGI |
Function
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0090543 | Flemming body |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0097352 | autophagosome maturation |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway |
| Biological Process | GO:1904903 | ESCRT III complex disassembly |
| Biological Process | GO:0061738 | late endosomal microautophagy |
| Biological Process | GO:0061764 | late endosome to lysosome transport via multivesicular body sorting pathway |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:0090148 | membrane fission |
| Biological Process | GO:0061952 | midbody abscission |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0036258 | multivesicular body assembly |
| Biological Process | GO:0071985 | multivesicular body sorting pathway |
| Biological Process | GO:1903542 | negative regulation of exosomal secretion |
| Biological Process | GO:0031468 | nuclear membrane reassembly |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0001778 | plasma membrane repair |
| Biological Process | GO:1903724 | positive regulation of centriole elongation |
| Biological Process | GO:1903543 | positive regulation of exosomal secretion |
| Biological Process | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:0051261 | protein depolymerization |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
| Biological Process | GO:1901673 | regulation of mitotic spindle assembly |
| Biological Process | GO:0033993 | response to lipid |
| Biological Process | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0007033 | vacuole organization |
| Biological Process | GO:0046761 | viral budding from plasma membrane |
| Biological Process | GO:0039702 | viral budding via host ESCRT complex |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.