Search Results

Overview

Uniprot IDO75362
Protein NameZinc finger protein 217
Gene NameZNF217
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
110 EYLSPLDKSQVRTEP
151 EIHMRTHKDSFTYGC
166 NMCGRRFKEPWFLKN
187 GKSGARSKLQQGLES
348 CAGLSQEKEKCKHSH
352 SQEKEKCKHSHGEAP
366 PSVDADPKLPSSKEK
371 DPKLPSSKEKPTHCS
373 KLPSSKEKPTHCSEC
457 PEGIHLDKNDDGGKI
463 DKNDDGGKIKHLTSS
465 NDDGGKIKHLTSSRE
478 RECSYCGKFFRSNYY
555 TADSAQTKNLKRFFD
565 KRFFDGAKDVTGSPP
574 VTGSPPAKQLKEMPS
577 SPPAKQLKEMPSVFQ
616 DSADKVNKNPTPAYL
627 PAYLDLLKKRSAVET
628 AYLDLLKKRSAVETQ
644 NNLICRTKADVTPPP
734 MHQRLEHKYNPDVHK
741 KYNPDVHKNCRNKSL
777 SFCKPKPKSAFPAQS
785 SAFPAQSKSLPSAKG
791 SKSLPSAKGKQSPPG
853 SVSPAPDKTKRPETK
855 SPAPDKTKRPETKLK
918 EFGEPLPKRLKSSVV
921 EPLPKRLKSSVVALD

Function

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'

Protein Sequence

10 MQSKVTGNMP 20 TQSLLMYMDG 30 PEVIGSSLGS 40 PMEMEDALSM 50 KGTAVVPFRA 60 TQEKNVIQIE 70 GYMPLDCMFC 80 SQTFTHSEDL 90 NKHVLMQHRP 100 TLCEPAVLRV 110 EAEYLSPLDK 120 SQVRTEPPKE 130 KNCKENEFSC 140 EVCGQTFRVA 150 FDVEIHMRTH 160 KDSFTYGCNM 170 CGRRFKEPWF 180 LKNHMRTHNG 190 KSGARSKLQQ 200 GLESSPATIN 210 EVVQVHAAES 220 ISSPYKICMV 230 CGFLFPNKES 240 LIEHRKVHTK 250 KTAFGTSSAQ 260 TDSPQGGMPS 270 SREDFLQLFN 280 LRPKSHPETG 290 KKPVRCIPQL 300 DPFTTFQAWQ 310 LATKGKVAIC 320 QEVKESGQEG 330 STDNDDSSSE 340 KELGETNKGS 350 CAGLSQEKEK 360 CKHSHGEAPS 370 VDADPKLPSS 380 KEKPTHCSEC 390 GKAFRTYHQL 400 VLHSRVHKKD 410 RRAGAESPTM 420 SVDGRQPGTC 430 SPDLAAPLDE 440 NGAVDRGEGG 450 SEDGSEDGLP 460 EGIHLDKNDD 470 GGKIKHLTSS 480 RECSYCGKFF 490 RSNYYLNIHL 500 RTHTGEKPYK 510 CEFCEYAAAQ 520 KTSLRYHLER 530 HHKEKQTDVA 540 AEVKNDGKNQ 550 DTEDALLTAD 560 SAQTKNLKRF 570 FDGAKDVTGS 580 PPAKQLKEMP 590 SVFQNVLGSA 600 VLSPAHKDTQ 610 DFHKNAADDS 620 ADKVNKNPTP 630 AYLDLLKKRS 640 AVETQANNLI 650 CRTKADVTPP 660 PDGSTTHNLE 670 VSPKEKQTET 680 AADCRYRPSV 690 DCHEKPLNLS 700 VGALHNCPAI 710 SLSKSLIPSI 720 TCPFCTFKTF 730 YPEVLMMHQR 740 LEHKYNPDVH 750 KNCRNKSLLR 760 SRRTGCPPAL 770 LGKDVPPLSS 780 FCKPKPKSAF 790 PAQSKSLPSA 800 KGKQSPPGPG 810 KAPLTSGIDS 820 STLAPSNLKS 830 HRPQQNVGVQ 840 GAATRQQQSE 850 MFPKTSVSPA 860 PDKTKRPETK 870 LKPLPVAPSQ 880 PTLGSSNING 890 SIDYPAKNDS 900 PWAPPGRDYF 910 CNRSASNTAA 920 EFGEPLPKRL 930 KSSVVALDVD 940 QPGANYRRGY 950 DLPKYHMVRG 960 ITSLLPQDCV 970 YPSQALPPKP 980 RFLSSSEVDS 990 PNVLTVQKPY 1000 GGSGPLYTCV 1010 PAGSPASSST 1020 LEGKRPVSYQ 1030 HLSNSMAQKR 1040 NYENFIGNAH YRPNDKKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.