Search Results
Overview
| Uniprot ID | O75368 |
|---|---|
| Protein Name | Adapter SH3BGRL |
| Gene Name | SH3BGRL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 17 | SSGSTAIKKKQQDVL |
Function
Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs (PubMed:34331014). May function as a ubiquitin ligase-substrate adapter (PubMed:34331014, PubMed:34870550). Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs (PubMed:34331014, PubMed:34870550)
Protein Sequence
10
MVIRVYIASS
20
SGSTAIKKKQ
30
QDVLGFLEAN
40
KIGFEEKDIA
50
ANEENRKWMR
60
ENVPENSRPA
70
TGYPLPPQIF
80
NESQYRGDYD
90
AFFEARENNA
100
VYAFLGLTAP
110
PGSKEAEVQA
KQQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0140517 | protein-RNA adaptor activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity |
| Biological Process | GO:1904690 | positive regulation of cytoplasmic translational initiation |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.