Search Results

Overview

Uniprot IDO75369
Protein NameFilamin-B
Gene NameFLNB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1005 GRENSTAKFIPREEG
1221 PHFPARVKVEPAVDT
1319 PIPNSPFKVAVTEGC
1379 KINCRDNKDGSCSAE
1416 SPFRVPVKDVVDPSK
1425 VVDPSKVKIAGPGLG
15 LAEDAPWKKIQQNTF
1510 PRSPFKVKVLPTYDA
1519 LPTYDASKVTASGPG
1572 RAIVHDNKDGTYAVT
1757 VIPFAVRKGEITGEV
1780 TPEIVDNKDGTVTVR
1872 EISCIDNKDGTCTVT
1979 GEHLVSIKKNGNHVA
1980 EHLVSIKKNGNHVAN
2044 LAVEGPSKVDIQTED
2058 DLEDGTCKVSYFPTV
2120 SICDLNLKIPEINSS
2150 AEIVPMGKNSHCVRF
2244 EITFDDHKNGSCGVS
2342 VSELEPDKYAVRFIP
241 LSQFPKAKLKPGAPL
2507 TCYSAIPKASSDASK
2518 DASKVTSKGAGLSKA
2530 SKAFVGQKSSFLVDC
2576 YNVTYVVKERGDYVL
313 TPDSDKNKTYSVEYL
322 YSVEYLPKVTGLHKV
349 PFEVSVDKAQGDASK
465 SGRGLQPKGVRIRET
495 GVTMKGPKGLEELVK
6 **MPVTEKDLAEDAP
60 LLEVLSQKRMYRKYH
607 NDGSCDVKYWPKEPG
681 DAGKAPLKIFAQDGE
697 QRIDIQMKNRMDGTY
744 GQGSHPQKVKVFGPG
782 GDVSVGIKCDARVLS
838 PASPFRVKVDPSHDA
948 PLDLSKIKLNGLENR
987 TILSPSRKVVPCLVT

Function

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro

Protein Sequence

10 MPVTEKDLAE 20 DAPWKKIQQN 30 TFTRWCNEHL 40 KCVNKRIGNL 50 QTDLSDGLRL 60 IALLEVLSQK 70 RMYRKYHQRP 80 TFRQMQLENV 90 SVALEFLDRE 100 SIKLVSIDSK 110 AIVDGNLKLI 120 LGLVWTLILH 130 YSISMPVWED 140 EGDDDAKKQT 150 PKQRLLGWIQ 160 NKIPYLPITN 170 FNQNWQDGKA 180 LGALVDSCAP 190 GLCPDWESWD 200 PQKPVDNARE 210 AMQQADDWLG 220 VPQVITPEEI 230 IHPDVDEHSV 240 MTYLSQFPKA 250 KLKPGAPLKP 260 KLNPKKARAY 270 GRGIEPTGNM 280 VKQPAKFTVD 290 TISAGQGDVM 300 VFVEDPEGNK 310 EEAQVTPDSD 320 KNKTYSVEYL 330 PKVTGLHKVT 340 VLFAGQHISK 350 SPFEVSVDKA 360 QGDASKVTAK 370 GPGLEAVGNI 380 ANKPTYFDIY 390 TAGAGVGDIG 400 VEVEDPQGKN 410 TVELLVEDKG 420 NQVYRCVYKP 430 MQPGPHVVKI 440 FFAGDTIPKS 450 PFVVQVGEAC 460 NPNACRASGR 470 GLQPKGVRIR 480 ETTDFKVDTK 490 AAGSGELGVT 500 MKGPKGLEEL 510 VKQKDFLDGV 520 YAFEYYPSTP 530 GRYSIAITWG 540 GHHIPKSPFE 550 VQVGPEAGMQ 560 KVRAWGPGLH 570 GGIVGRSADF 580 VVESIGSEVG 590 SLGFAIEGPS 600 QAKIEYNDQN 610 DGSCDVKYWP 620 KEPGEYAVHI 630 MCDDEDIKDS 640 PYMAFIHPAT 650 GGYNPDLVRA 660 YGPGLEKSGC 670 IVNNLAEFTV 680 DPKDAGKAPL 690 KIFAQDGEGQ 700 RIDIQMKNRM 710 DGTYACSYTP 720 VKAIKHTIAV 730 VWGGVNIPHS 740 PYRVNIGQGS 750 HPQKVKVFGP 760 GVERSGLKAN 770 EPTHFTVDCT 780 EAGEGDVSVG 790 IKCDARVLSE 800 DEEDVDFDII 810 HNANDTFTVK 820 YVPPAAGRYT 830 IKVLFASQEI 840 PASPFRVKVD 850 PSHDASKVKA 860 EGPGLSKAGV 870 ENGKPTHFTV 880 YTKGAGKAPL 890 NVQFNSPLPG 900 DAVKDLDIID 910 NYDYSHTVKY 920 TPTQQGNMQV 930 LVTYGGDPIP 940 KSPFTVGVAA 950 PLDLSKIKLN 960 GLENRVEVGK 970 DQEFTVDTRG 980 AGGQGKLDVT 990 ILSPSRKVVP 1000 CLVTPVTGRE 1010 NSTAKFIPRE 1020 EGLYAVDVTY 1030 DGHPVPGSPY 1040 TVEASLPPDP 1050 SKVKAHGPGL 1060 EGGLVGKPAE 1070 FTIDTKGAGT 1080 GGLGLTVEGP 1090 CEAKIECSDN 1100 GDGTCSVSYL 1110 PTKPGEYFVN 1120 ILFEEVHIPG 1130 SPFKADIEMP 1140 FDPSKVVASG 1150 PGLEHGKVGE 1160 AGLLSVDCSE 1170 AGPGALGLEA 1180 VSDSGTKAEV 1190 SIQNNKDGTY 1200 AVTYVPLTAG 1210 MYTLTMKYGG 1220 ELVPHFPARV 1230 KVEPAVDTSR 1240 IKVFGPGIEG 1250 KDVFREATTD 1260 FTVDSRPLTQ 1270 VGGDHIKAHI 1280 ANPSGASTEC 1290 FVTDNADGTY 1300 QVEYTPFEKG 1310 LHVVEVTYDD 1320 VPIPNSPFKV 1330 AVTEGCQPSR 1340 VQAQGPGLKE 1350 AFTNKPNVFT 1360 VVTRGAGIGG 1370 LGITVEGPSE 1380 SKINCRDNKD 1390 GSCSAEYIPF 1400 APGDYDVNIT 1410 YGGAHIPGSP 1420 FRVPVKDVVD 1430 PSKVKIAGPG 1440 LGSGVRARVL 1450 QSFTVDSSKA 1460 GLAPLEVRVL 1470 GPRGLVEPVN 1480 VVDNGDGTHT 1490 VTYTPSQEGP 1500 YMVSVKYADE 1510 EIPRSPFKVK 1520 VLPTYDASKV 1530 TASGPGLSSY 1540 GVPASLPVDF 1550 AIDARDAGEG 1560 LLAVQITDQE 1570 GKPKRAIVHD 1580 NKDGTYAVTY 1590 IPDKTGRYMI 1600 GVTYGGDDIP 1610 LSPYRIRATQ 1620 TGDASKCLAT 1630 GPGIASTVKT 1640 GEEVGFVVDA 1650 KTAGKGKVTC 1660 TVLTPDGTEA 1670 EADVIENEDG 1680 TYDIFYTAAK 1690 PGTYVIYVRF 1700 GGVDIPNSPF 1710 TVMATDGEVT 1720 AVEEAPVNAC 1730 PPGFRPWVTE 1740 EAYVPVSDMN 1750 GLGFKPFDLV 1760 IPFAVRKGEI 1770 TGEVHMPSGK 1780 TATPEIVDNK 1790 DGTVTVRYAP 1800 TEVGLHEMHI 1810 KYMGSHIPES 1820 PLQFYVNYPN 1830 SGSVSAYGPG 1840 LVYGVANKTA 1850 TFTIVTEDAG 1860 EGGLDLAIEG 1870 PSKAEISCID 1880 NKDGTCTVTY 1890 LPTLPGDYSI 1900 LVKYNDKHIP 1910 GSPFTAKITD 1920 DSRRCSQVKL 1930 GSAADFLLDI 1940 SETDLSSLTA 1950 SIKAPSGRDE 1960 PCLLKRLPNN 1970 HIGISFIPRE 1980 VGEHLVSIKK 1990 NGNHVANSPV 2000 SIMVVQSEIG 2010 DARRAKVYGR 2020 GLSEGRTFEM 2030 SDFIVDTRDA 2040 GYGGISLAVE 2050 GPSKVDIQTE 2060 DLEDGTCKVS 2070 YFPTVPGVYI 2080 VSTKFADEHV 2090 PGSPFTVKIS 2100 GEGRVKESIT 2110 RTSRAPSVAT 2120 VGSICDLNLK 2130 IPEINSSDMS 2140 AHVTSPSGRV 2150 TEAEIVPMGK 2160 NSHCVRFVPQ 2170 EMGVHTVSVK 2180 YRGQHVTGSP 2190 FQFTVGPLGE 2200 GGAHKVRAGG 2210 PGLERGEAGV 2220 PAEFSIWTRE 2230 AGAGGLSIAV 2240 EGPSKAEITF 2250 DDHKNGSCGV 2260 SYIAQEPGNY 2270 EVSIKFNDEH 2280 IPESPYLVPV 2290 IAPSDDARRL 2300 TVMSLQESGL 2310 KVNQPASFAI 2320 RLNGAKGKID 2330 AKVHSPSGAV 2340 EECHVSELEP 2350 DKYAVRFIPH 2360 ENGVHTIDVK 2370 FNGSHVVGSP 2380 FKVRVGEPGQ 2390 AGNPALVSAY 2400 GTGLEGGTTG 2410 IQSEFFINTT 2420 RAGPGTLSVT 2430 IEGPSKVKMD 2440 CQETPEGYKV 2450 MYTPMAPGNY 2460 LISVKYGGPN 2470 HIVGSPFKAK 2480 VTGQRLVSPG 2490 SANETSSILV 2500 ESVTRSSTET 2510 CYSAIPKASS 2520 DASKVTSKGA 2530 GLSKAFVGQK 2540 SSFLVDCSKA 2550 GSNMLLIGVH 2560 GPTTPCEEVS 2570 MKHVGNQQYN 2580 VTYVVKERGD 2590 YVLAVKWGEE 2600 HIPGSPFHVT VP

Gene Ontology

Classification GO ID Description
Molecular Function GO:0003723 RNA binding
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005903 brush border
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007517 muscle organ development
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.