Search Results

Overview

Uniprot IDO75376
Protein NameNuclear receptor corepressor 1
Gene NameNCOR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 DHDSLESKRPRLEQV
1098 PRQQESAKSATLPYI
1106 SATLPYIKQEEFSPR
1152 TRGTPTSKISVESIP
1184 IPTEALVKGSISRMP
1207 GREEAASKGHVIYEG
1215 GHVIYEGKSGHILSY
1226 ILSYDNIKNAREGTR
1244 TAHEISLKRSYESVE
1255 ESVEGNIKQGMSMRE
1287 GSPHSDLKERTVLSG
1313 ESFEDGLKYPKQIKR
1316 EDGLKYPKQIKRESP
1334 AFEGAITKGKPYDGI
1336 EGAITKGKPYDGITT
1345 YDGITTIKEMGRSIH
1366 ILTQESRKTPEVVQS
1389 ISQGTPIKFDNNSGQ
1400 NSGQSAIKHNVKSLI
1404 SAIKHNVKSLITGPS
1412 SLITGPSKLSRGMPP
1439 RGKYEDVKAGETVRS
144 LRASADAKKDPAFGG
1468 STLHEAPKAQLSPGI
1511 DVTISSNKSTNHERK
1518 KSTNHERKSTLTPTQ
1532 QRESIPAKSPVPGVD
1875 QKTLEVEKRSVQCLY
1945 TRQIASDKDARERGS
1998 TYQPEVVKANQAEND
201 KVEQQILKLKKKQQQ
2127 SPENLVDKSRGSRPG
2206 ENTSPMVKSKKQEIF
2208 TSPMVKSKKQEIFRK
2269 GLEDIIRKALMGSFD
2278 LMGSFDDKVEDHGVV
2323 PHSGGVCKPKLISKS
2329 CKPKLISKSNSRKSK
288 TNQVMRKKLILFFKR
294 KKLILFFKRRNHARK
344 KTREYYEKQFPEIRK
524 KEEDKAEKTEKKEEE
551 SKENTKEKDKIDGTA
553 ENTKEKDKIDGTAEE
637 EEEMEVAKKGLVEHG
638 EEMEVAKKGLVEHGR
652 RNWAAIAKMVGTKSE
663 TKSEAQCKNFYFNYK
670 KNFYFNYKRRHNLDN
683 DNLLQQHKQKTSRKP
685 LLQQHKQKTSRKPRE
835 VPENHASKVEGDNTK
852 DLDRASEKVEPRDED
965 ALYQRHIKAMHESAL
998 TSPCGTSKSPNREWE

Function

Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity)

Protein Sequence

10 MSSSGYPPNQ 20 GAFSTEQSRY 30 PPHSVQYTFP 40 NTRHQQEFAV 50 PDYRSSHLEV 60 SQASQLLQQQ 70 QQQQLRRRPS 80 LLSEFHPGSD 90 RPQERRTSYE 100 PFHPGPSPVD 110 HDSLESKRPR 120 LEQVSDSHFQ 130 RVSAAVLPLV 140 HPLPEGLRAS 150 ADAKKDPAFG 160 GKHEAPSSPI 170 SGQPCGDDQN 180 ASPSKLSKEE 190 LIQSMDRVDR 200 EIAKVEQQIL 210 KLKKKQQQLE 220 EEAAKPPEPE 230 KPVSPPPVEQ 240 KHRSIVQIIY 250 DENRKKAEEA 260 HKIFEGLGPK 270 VELPLYNQPS 280 DTKVYHENIK 290 TNQVMRKKLI 300 LFFKRRNHAR 310 KQREQKICQR 320 YDQLMEAWEK 330 KVDRIENNPR 340 RKAKESKTRE 350 YYEKQFPEIR 360 KQREQQERFQ 370 RVGQRGAGLS 380 ATIARSEHEI 390 SEIIDGLSEQ 400 ENNEKQMRQL 410 SVIPPMMFDA 420 EQRRVKFINM 430 NGLMEDPMKV 440 YKDRQFMNVW 450 TDHEKEIFKD 460 KFIQHPKNFG 470 LIASYLERKS 480 VPDCVLYYYL 490 TKKNENYKAL 500 VRRNYGKRRG 510 RNQQIARPSQ 520 EEKVEEKEED 530 KAEKTEKKEE 540 EKKDEEEKDE 550 KEDSKENTKE 560 KDKIDGTAEE 570 TEEREQATPR 580 GRKTANSQGR 590 RKGRITRSMT 600 NEAAAASAAA 610 AAATEEPPPP 620 LPPPPEPIST 630 EPVETSRWTE 640 EEMEVAKKGL 650 VEHGRNWAAI 660 AKMVGTKSEA 670 QCKNFYFNYK 680 RRHNLDNLLQ 690 QHKQKTSRKP 700 REERDVSQCE 710 SVASTVSAQE 720 DEDIEASNEE 730 ENPEDSEVEA 740 VKPSEDSPEN 750 ATSRGNTEPA 760 VELEPTTETA 770 PSTSPSLAVP 780 STKPAEDESV 790 ETQVNDSISA 800 ETAEQMDVDQ 810 QEHSAEEGSV 820 CDPPPATKAD 830 SVDVEVRVPE 840 NHASKVEGDN 850 TKERDLDRAS 860 EKVEPRDEDL 870 VVAQQINAQR 880 PEPQSDNDSS 890 ATCSADEDVD 900 GEPERQRMFP 910 MDSKPSLLNP 920 TGSILVSSPL 930 KPNPLDLPQL 940 QHRAAVIPPM 950 VSCTPCNIPI 960 GTPVSGYALY 970 QRHIKAMHES 980 ALLEEQRQRQ 990 EQIDLECRSS 1000 TSPCGTSKSP 1010 NREWEVLQPA 1020 PHQVITNLPE 1030 GVRLPTTRPT 1040 RPPPPLIPSS 1050 KTTVASEKPS 1060 FIMGGSISQG 1070 TPGTYLTSHN 1080 QASYTQETPK 1090 PSVGSISLGL 1100 PRQQESAKSA 1110 TLPYIKQEEF 1120 SPRSQNSQPE 1130 GLLVRAQHEG 1140 VVRGTAGAIQ 1150 EGSITRGTPT 1160 SKISVESIPS 1170 LRGSITQGTP 1180 ALPQTGIPTE 1190 ALVKGSISRM 1200 PIEDSSPEKG 1210 REEAASKGHV 1220 IYEGKSGHIL 1230 SYDNIKNARE 1240 GTRSPRTAHE 1250 ISLKRSYESV 1260 EGNIKQGMSM 1270 RESPVSAPLE 1280 GLICRALPRG 1290 SPHSDLKERT 1300 VLSGSIMQGT 1310 PRATTESFED 1320 GLKYPKQIKR 1330 ESPPIRAFEG 1340 AITKGKPYDG 1350 ITTIKEMGRS 1360 IHEIPRQDIL 1370 TQESRKTPEV 1380 VQSTRPIIEG 1390 SISQGTPIKF 1400 DNNSGQSAIK 1410 HNVKSLITGP 1420 SKLSRGMPPL 1430 EIVPENIKVV 1440 ERGKYEDVKA 1450 GETVRSRHTS 1460 VVSSGPSVLR 1470 STLHEAPKAQ 1480 LSPGIYDDTS 1490 ARRTPVSYQN 1500 TMSRGSPMMN 1510 RTSDVTISSN 1520 KSTNHERKST 1530 LTPTQRESIP 1540 AKSPVPGVDP 1550 VVSHSPFDPH 1560 HRGSTAGEVY 1570 RSHLPTHLDP 1580 AMPFHRALDP 1590 AAAAYLFQRQ 1600 LSPTPGYPSQ 1610 YQLYAMENTR 1620 QTILNDYITS 1630 QQMQVNLRPD 1640 VARGLSPREQ 1650 PLGLPYPATR 1660 GIIDLTNMPP 1670 TILVPHPGGT 1680 STPPMDRITY 1690 IPGTQITFPP 1700 RPYNSASMSP 1710 GHPTHLAAAA 1720 SAERERERER 1730 EKERERERIA 1740 AASSDLYLRP 1750 GSEQPGRPGS 1760 HGYVRSPSPS 1770 VRTQETMLQQ 1780 RPSVFQGTNG 1790 TSVITPLDPT 1800 AQLRIMPLPA 1810 GGPSISQGLP 1820 ASRYNTAADA 1830 LAALVDAAAS 1840 APQMDVSKTK 1850 ESKHEAARLE 1860 ENLRSRSAAV 1870 SEQQQLEQKT 1880 LEVEKRSVQC 1890 LYTSSAFPSG 1900 KPQPHSSVVY 1910 SEAGKDKGPP 1920 PKSRYEEELR 1930 TRGKTTITAA 1940 NFIDVIITRQ 1950 IASDKDARER 1960 GSQSSDSSSS 1970 LSSHRYETPS 1980 DAIEVISPAS 1990 SPAPPQEKLQ 2000 TYQPEVVKAN 2010 QAENDPTRQY 2020 EGPLHHYRPQ 2030 QESPSPQQQL 2040 PPSSQAEGMG 2050 QVPRTHRLIT 2060 LADHICQIIT 2070 QDFARNQVSS 2080 QTPQQPPTST 2090 FQNSPSALVS 2100 TPVRTKTSNR 2110 YSPESQAQSV 2120 HHQRPGSRVS 2130 PENLVDKSRG 2140 SRPGKSPERS 2150 HVSSEPYEPI 2160 SPPQVPVVHE 2170 KQDSLLLLSQ 2180 RGAEPAEQRN 2190 DARSPGSISY 2200 LPSFFTKLEN 2210 TSPMVKSKKQ 2220 EIFRKLNSSG 2230 GGDSDMAAAQ 2240 PGTEIFNLPA 2250 VTTSGSVSSR 2260 GHSFADPASN 2270 LGLEDIIRKA 2280 LMGSFDDKVE 2290 DHGVVMSQPM 2300 GVVPGTANTS 2310 VVTSGETRRE 2320 EGDPSPHSGG 2330 VCKPKLISKS 2340 NSRKSKSPIP 2350 GQGYLGTERP 2360 SSVSSVHSEG 2370 DYHRQTPGWA 2380 WEDRPSSTGS 2390 TQFPYNPLTM 2400 RMLSSTPPTP 2410 IACAPSAVNQ 2420 AAPHQQNRIW 2430 EREPAPLLSA 2440 QYETLSDSDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045475 locomotor rhythm
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045922 negative regulation of fatty acid metabolic process
Biological Process GO:0045820 negative regulation of glycolytic process
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:1902894 negative regulation of miRNA transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0060633 negative regulation of transcription initiation by RNA polymerase II
Biological Process GO:0051225 spindle assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.