Search Results
Overview
| Uniprot ID | O75380 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial |
| Gene Name | NDUFS6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | KVYINLDKETKTGTC |
| 108 | INLDKETKTGTCGYC |
| 38 | RVSPTGEKVTHTGQV |
| 98 | GGALGHPKVYINLDK |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MAAAMTFCRL
20
LNRCGEAARS
30
LPLGARCFGV
40
RVSPTGEKVT
50
HTGQVYDDKD
60
YRRIRFVGRQ
70
KEVNENFAID
80
LIAEQPVSEV
90
ETRVIACDGG
100
GGALGHPKVY
110
INLDKETKTG
120
TCGYCGLQFR
QHHH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.