Overview
| Uniprot ID | O75381 |
|---|
| Protein Name | Peroxisomal membrane protein PEX14 |
|---|
| Gene Name | PEX14 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 363 |
QINEQVEKLRRPEGA |
Function
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035)
Protein Sequence
10
MASSEQAEQP
20
SQPSSTPGSE
30
NVLPREPLIA
40
TAVKFLQNSR
50
VRQSPLATRR
60
AFLKKKGLTD
70
EEIDMAFQQS
80
GTAADEPSSL
90
GPATQVVPVQ
100
PPHLISQPYS
110
PAGSRWRDYG
120
ALAIIMAGIA
130
FGFHQLYKKY
140
LLPLILGGRE
150
DRKQLERMEA
160
GLSELSGSVA
170
QTVTQLQTTL
180
ASVQELLIQQ
190
QQKIQELAHE
200
LAAAKATTST
210
NWILESQNIN
220
ELKSEINSLK
230
GLLLNRRQFP
240
PSPSAPKIPS
250
WQIPVKSPSP
260
SSPAAVNHHS
270
SSDISPVSNE
280
STSSSPGKEG
290
HSPEGSTVTY
300
HLLGPQEEGE
310
GVVDVKGQVR
320
MEVQGEEEKR
330
EDKEDEEDEE
340
DDDVSHVDEE
350
DCLGVQREDR
360
RGGDGQINEQ
370
VEKLRRPEGA
SNESERD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005777 |
peroxisome |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:1990429 |
peroxisomal importomer complex |
| Cellular Component |
GO:0005778 |
peroxisomal membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0048487 |
beta-tubulin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0008320 |
protein transmembrane transporter activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0034614 |
cellular response to reactive oxygen species |
| Biological Process |
GO:0034453 |
microtubule anchoring |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0007031 |
peroxisome organization |
| Biological Process |
GO:0036250 |
peroxisome transport along microtubule |
| Biological Process |
GO:0016558 |
protein import into peroxisome matrix |
| Biological Process |
GO:0016560 |
protein import into peroxisome matrix, docking |
| Biological Process |
GO:0044721 |
protein import into peroxisome matrix, substrate release |
| Biological Process |
GO:0016561 |
protein import into peroxisome matrix, translocation |
| Biological Process |
GO:0065003 |
protein-containing complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.