Overview
| Uniprot ID | O75382 |
|---|
| Protein Name | Tripartite motif-containing protein 3 |
|---|
| Gene Name | TRIM3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 464 |
YSTGGKRKDNPIEDE |
Function
E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999)
Protein Sequence
10
MAKREDSPGP
20
EVQPMDKQFL
30
VCSICLDRYQ
40
CPKVLPCLHT
50
FCERCLQNYI
60
PAQSLTLSCP
70
VCRQTSILPE
80
QGVSALQNNF
90
FISSLMEAMQ
100
QAPDGAHDPE
110
DPHPLSVVAG
120
RPLSCPNHEG
130
KTMEFYCEAC
140
ETAMCGECRA
150
GEHREHGTVL
160
LRDVVEQHKA
170
ALQRQLEAVR
180
GRLPQLSAAI
190
ALVGGISQQL
200
QERKAEALAQ
210
ISAAFEDLEQ
220
ALQQRKQALV
230
SDLETICGAK
240
QKVLQSQLDT
250
LRQGQEHIGS
260
SCSFAEQALR
270
LGSAPEVLLV
280
RKHMRERLAA
290
LAAQAFPERP
300
HENAQLELVL
310
EVDGLRRSVL
320
NLGALLTTSA
330
TAHETVATGE
340
GLRQALVGQP
350
ASLTVTTKDK
360
DGRLVRTGSA
370
ELRAEITGPD
380
GTRLPVPVVD
390
HKNGTYELVY
400
TARTEGELLL
410
SVLLYGQPVR
420
GSPFRVRALR
430
PGDLPPSPDD
440
VKRRVKSPGG
450
PGSHVRQKAV
460
RRPSSMYSTG
470
GKRKDNPIED
480
ELVFRVGSRG
490
REKGEFTNLQ
500
GVSAASSGRI
510
VVADSNNQCI
520
QVFSNEGQFK
530
FRFGVRGRSP
540
GQLQRPTGVA
550
VDTNGDIIVA
560
DYDNRWVSIF
570
SPEGKFKTKI
580
GAGRLMGPKG
590
VAVDRNGHII
600
VVDNKSCCVF
610
TFQPNGKLVG
620
RFGGRGATDR
630
HFAGPHFVAV
640
NNKNEIVVTD
650
FHNHSVKVYS
660
ADGEFLFKFG
670
SHGEGNGQFN
680
APTGVAVDSN
690
GNIIVADWGN
700
SRIQVFDSSG
710
SFLSYINTSA
720
EPLYGPQGLA
730
LTSDGHVVVA
740
DAGNHCFKAY
RYLQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0061630 |
ubiquitin protein ligase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0061351 |
neural precursor cell proliferation |
| Biological Process |
GO:0034141 |
positive regulation of toll-like receptor 3 signaling pathway |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0070534 |
protein K63-linked ubiquitination |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.