Search Results

Overview

Uniprot IDO75390
Protein NameCitrate synthase, mitochondrial
Gene NameCS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 FSIPECQKLLPKAKG
215 KLPCVAAKIYRNLYR
321 QLQKEVGKDVSDEKL
327 GKDVSDEKLRDYIWN
366 CQREFALKHLPNDPM
43 ILADLIPKEQARIKT
450 GFPLERPKSMSTEGL
459 MSTEGLMKFVDSKSG
57 TFRQQHGKTVVGQIT
76 YGGMRGMKGLVYETS

Function

Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate

Protein Sequence

10 MALLTAAARL 20 LGTKNASCLV 30 LAARHASASS 40 TNLKDILADL 50 IPKEQARIKT 60 FRQQHGKTVV 70 GQITVDMMYG 80 GMRGMKGLVY 90 ETSVLDPDEG 100 IRFRGFSIPE 110 CQKLLPKAKG 120 GEEPLPEGLF 130 WLLVTGHIPT 140 EEQVSWLSKE 150 WAKRAALPSH 160 VVTMLDNFPT 170 NLHPMSQLSA 180 AVTALNSESN 190 FARAYAQGIS 200 RTKYWELIYE 210 DSMDLIAKLP 220 CVAAKIYRNL 230 YREGSGIGAI 240 DSNLDWSHNF 250 TNMLGYTDHQ 260 FTELTRLYLT 270 IHSDHEGGNV 280 SAHTSHLVGS 290 ALSDPYLSFA 300 AAMNGLAGPL 310 HGLANQEVLV 320 WLTQLQKEVG 330 KDVSDEKLRD 340 YIWNTLNSGR 350 VVPGYGHAVL 360 RKTDPRYTCQ 370 REFALKHLPN 380 DPMFKLVAQL 390 YKIVPNVLLE 400 QGKAKNPWPN 410 VDAHSGVLLQ 420 YYGMTEMNYY 430 TVLFGVSRAL 440 GVLAQLIWSR 450 ALGFPLERPK 460 SMSTEGLMKF VDSKSG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0036440 citrate synthase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.