Search Results
Overview
| Uniprot ID | O75396 |
|---|---|
| Protein Name | Vesicle-trafficking protein SEC22b |
| Gene Name | SEC22B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | FDEQHGKKVPTVSRP |
| 124 | TFIQKTKKLYIDSRA |
| 169 | ALSALDSKANNLSSL |
| 43 | QAKQLFRKLNEQSPT |
Function
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000421 | autophagosome membrane |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:1902902 | negative regulation of autophagosome assembly |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Biological Process | GO:0006906 | vesicle fusion |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0030133 | transport vesicle |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Biological Process | GO:0009267 | cellular response to starvation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.