Search Results
Overview
| Uniprot ID | O75400 |
|---|---|
| Protein Name | Pre-mRNA-processing factor 40 homolog A |
| Gene Name | PRPF40A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 184 | PAEQLLSKCPWKEYK |
Function
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing
Protein Sequence
10
MRPGTGAERG
20
GLMVSEMESH
30
PPSQGPGDGE
40
RRLSGSSLCS
50
GSWVSADGFL
60
RRRPSMGHPG
70
MHYAPMGMHP
80
MGQRANMPPV
90
PHGMMPQMMP
100
PMGGPPMGQM
110
PGMMSSVMPG
120
MMMSHMSQAS
130
MQPALPPGVN
140
SMDVAAGTAS
150
GAKSMWTEHK
160
SPDGRTYYYN
170
TETKQSTWEK
180
PDDLKTPAEQ
190
LLSKCPWKEY
200
KSDSGKPYYY
210
NSQTKESRWA
220
KPKELEDLEG
230
YQNTIVAGSL
240
ITKSNLHAMI
250
KAEESSKQEE
260
CTTTSTAPVP
270
TTEIPTTMST
280
MAAAEAAAAV
290
VAAAAAAAAA
300
AAAANANAST
310
SASNTVSGTV
320
PVVPEPEVTS
330
IVATVVDNEN
340
TVTISTEEQA
350
QLTSTPAIQD
360
QSVEVSSNTG
370
EETSKQETVA
380
DFTPKKEEEE
390
SQPAKKTYTW
400
NTKEEAKQAF
410
KELLKEKRVP
420
SNASWEQAMK
430
MIINDPRYSA
440
LAKLSEKKQA
450
FNAYKVQTEK
460
EEKEEARSKY
470
KEAKESFQRF
480
LENHEKMTST
490
TRYKKAEQMF
500
GEMEVWNAIS
510
ERDRLEIYED
520
VLFFLSKKEK
530
EQAKQLRKRN
540
WEALKNILDN
550
MANVTYSTTW
560
SEAQQYLMDN
570
PTFAEDEELQ
580
NMDKEDALIC
590
FEEHIRALEK
600
EEEEEKQKSL
610
LRERRRQRKN
620
RESFQIFLDE
630
LHEHGQLHSM
640
SSWMELYPTI
650
SSDIRFTNML
660
GQPGSTALDL
670
FKFYVEDLKA
680
RYHDEKKIIK
690
DILKDKGFVV
700
EVNTTFEDFV
710
AIISSTKRST
720
TLDAGNIKLA
730
FNSLLEKAEA
740
REREREKEEA
750
RKMKRKESAF
760
KSMLKQAAPP
770
IELDAVWEDI
780
RERFVKEPAF
790
EDITLESERK
800
RIFKDFMHVL
810
EHECQHHHSK
820
NKKHSKKSKK
830
HHRKRSRSRS
840
GSDSDDDDSH
850
SKKKRQRSES
860
RSASEHSSSA
870
ESERSYKKSK
880
KHKKKSKKRR
890
HKSDSPESDA
900
EREKDKKEKD
910
RESEKDRTRQ
920
RSESKHKSPK
930
KKTGKDSGNW
940
DTSGSELSEG
950
ELEKRRRTLL
EQLDDDQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005685 | U1 snRNP |
| Cellular Component | GO:0071004 | U2-type prespliceosome |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.