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Overview

Uniprot IDO75410
Protein NameTransforming acidic coiled-coil-containing protein 1
Gene NameTACC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
471 TSGCKVKKHETQSLA
517 ASTSCGQKSAGAEVK

Function

Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues

Protein Sequence

10 MAFSPWQILS 20 PVQWAKWTWS 30 AVRGGAAGED 40 EAGGPEGDPE 50 EEDSQAETKS 60 LSFSSDSEGN 70 FETPEAETPI 80 RSPFKESCDP 90 SLGLAGPGAK 100 SQESQEADEQ 110 LVAEVVEKCS 120 SKTCSKPSEN 130 EVPQQAIDSH 140 SVKNFREEPE 150 HDFSKISIVR 160 PFSIETKDST 170 DISAVLGTKA 180 AHGCVTAVSG 190 KALPSSPPDA 200 LQDEAMTEGS 210 MGVTLEASAE 220 ADLKAGNSCP 230 ELVPSRRSKL 240 RKPKPVPLRK 250 KAIGGEFSDT 260 NAAVEGTPLP 270 KASYHFSPEE 280 LDENTSPLLG 290 DARFQKSPPD 300 LKETPGTLSS 310 DTNDSGVELG 320 EESRSSPLKL 330 EFDFTEDTGN 340 IEARKALPRK 350 LGRKLGSTLT 360 PKIQKDGISK 370 SAGLEQPTDP 380 VARDGPLSQT 390 SSKPDPSQWE 400 SPSFNPFGSH 410 SVLQNSPPLS 420 SEGSYHFDPD 430 NFDESMDPFK 440 PTTTLTSSDF 450 CSPTGNHVNE 460 ILESPKKAKS 470 RLITSGCKVK 480 KHETQSLALD 490 ACSRDEGAVI 500 SQISDISNRD 510 GHATDEEKLA 520 STSCGQKSAG 530 AEVKGEPEED 540 LEYFECSNVP 550 VSTINHAFSS 560 SEAGIEKETC 570 QKMEEDGSTV 580 LGLLESSAEK 590 APVSVSCGGE 600 SPLDGICLSE 610 SDKTAVLTLI 620 REEIITKEIE 630 ANEWKKKYEE 640 TRQEVLEMRK 650 IVAEYEKTIA 660 QMIEDEQRTS 670 MTSQKSFQQL 680 TMEKEQALAD 690 LNSVERSLSD 700 LFRRYENLKG 710 VLEGFKKNEE 720 ALKKCAQDYL 730 ARVKQEEQRY 740 QALKIHAEEK 750 LDKANEEIAQ 760 VRTKAKAESA 770 ALHAGLRKEQ 780 MKVESLERAL 790 QQKNQEIEEL 800 TKICDELIAK LGKTD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0030496 midbody
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0042974 nuclear retinoic acid receptor binding
Molecular Function GO:0046965 nuclear retinoid X receptor binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0042975 peroxisome proliferator activated receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0030953 astral microtubule organization
Biological Process GO:0051301 cell division
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0007097 nuclear migration

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.