Search Results
Overview
| Uniprot ID | O75419 |
|---|---|
| Protein Name | Cell division control protein 45 homolog |
| Gene Name | CDC45 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 420 | YHGLELAKKQLRATQ |
Function
Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built
Protein Sequence
10
MFVSDFRKEF
20
YEVVQSQRVL
30
LFVASDVDAL
40
CACKILQALF
50
QCDHVQYTLV
60
PVSGWQELET
70
AFLEHKEQFH
80
YFILINCGAN
90
VDLLDILQPD
100
EDTIFFVCDT
110
HRPVNVVNVY
120
NDTQIKLLIK
130
QDDDLEVPAY
140
EDIFRDEEED
150
EEHSGNDSDG
160
SEPSEKRTRL
170
EEEIVEQTMR
180
RRQRREWEAR
190
RRDILFDYEQ
200
YEYHGTSSAM
210
VMFELAWMLS
220
KDLNDMLWWA
230
IVGLTDQWVQ
240
DKITQMKYVT
250
DVGVLQRHVS
260
RHNHRNEDEE
270
NTLSVDCTRI
280
SFEYDLRLVL
290
YQHWSLHDSL
300
CNTSYTAARF
310
KLWSVHGQKR
320
LQEFLADMGL
330
PLKQVKQKFQ
340
AMDISLKENL
350
REMIEESANK
360
FGMKDMRVQT
370
FSIHFGFKHK
380
FLASDVVFAT
390
MSLMESPEKD
400
GSGTDHFIQA
410
LDSLSRSNLD
420
KLYHGLELAK
430
KQLRATQQTI
440
ASCLCTNLVI
450
SQGPFLYCSL
460
MEGTPDVMLF
470
SRPASLSLLS
480
KHLLKSFVCS
490
TKNRRCKLLP
500
LVMAAPLSME
510
HGTVTVVGIP
520
PETDSSDRKN
530
FFGRAFEKAA
540
ESTSSRMLHN
550
HFDLSVIELK
560
AEDRSKFLDA
LISLLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031261 | DNA replication preinitiation complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003688 | DNA replication origin binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0000076 | DNA replication checkpoint signaling |
| Biological Process | GO:0006270 | DNA replication initiation |
| Biological Process | GO:0000727 | double-strand break repair via break-induced replication |
| Biological Process | GO:1902977 | mitotic DNA replication preinitiation complex assembly |
Reference
PMID: N/A