Search Results

Overview

Uniprot ID	O75420
Protein Name	GRB10-interacting GYF protein 1
Gene Name	GIGYF1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
249	EHGERRRKFEFDLRG

Function

May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity)

Protein Sequence

10 MAAETLNFGP 20 EWLRALSGGG 30 SVASPPPSPA 40 MPKYKLADYR 50 YGREEMLALY 60 VKENKVPEEL 70 QDKEFAAVLQ 80 DEPLQPLALE 90 PLTEEEQRNF 100 SLSVNSVAVL 110 RLMGKGAGPP 120 LAGTSRGRGS 130 TRSRGRGRGD 140 SCFYQRSIEE 150 GDGAFGRSPR 160 EIQRSQSWDD 170 RGERRFEKSA 180 RRDGARCGFE 190 EGGAGPRKEH 200 ARSDSENWRS 210 LREEQEEEEE 220 GSWRLGAGPR 230 RDGDRWRSAS 240 PDGGPRSAGW 250 REHGERRRKF 260 EFDLRGDRGG 270 CGEEEGRGGG 280 GSSHLRRCRA 290 PEGFEEDKDG 300 LPEWCLDDED 310 EEMGTFDASG 320 AFLPLKKGPK 330 EPIPEEQELD 340 FQGLEEEEEP 350 SEGLEEEGPE 360 AGGKELTPLP 370 PQEEKSSSPS 380 PLPTLGPLWG 390 TNGDGDETAE 400 KEPPAAEDDI 410 RGIQLSPGVG 420 SSAGPPGDLE 430 DDEGLKHLQQ 440 EAEKLVASLQ 450 DSSLEEEQFT 460 AAMQTQGLRH 470 SAAATALPLS 480 HGAARKWFYK 490 DPQGEIQGPF 500 TTQEMAEWFQ 510 AGYFSMSLLV 520 KRGCDEGFQP 530 LGEVIKMWGR 540 VPFAPGPSPP 550 PLLGNMDQER 560 LKKQQELAAA 570 ALYQQLQHQQ 580 FLQLVSSRQL 590 PQCALREKAA 600 LGDLTPPPPP 610 PPQQQQQQLT 620 AFLQQLQALK 630 PPRGGDQNLL 640 PTMSRSLSVP 650 DSGRLWDVHT 660 SASSQSGGEA 670 SLWDIPINSS 680 TQGPILEQLQ 690 LQHKFQERRE 700 VELRAKREEE 710 ERKRREEKRR 720 QQQQEEQKRR 730 QEEEELFRRK 740 HVRQQELLLK 750 LLQQQQAVPV 760 PPAPSSPPPL 770 WAGLAKQGLS 780 MKTLLELQLE 790 GERQLHKQPP 800 PREPARAQAP 810 NHRVQLGGLG 820 TAPLNQWVSE 830 AGPLWGGPDK 840 SGGGSSGLGL 850 WEDTPKSGGS 860 LVRGLGLKNS 870 RSSPSLSDSY 880 SHLSGRPIRK 890 KTEEEEKLLK 900 LLQGIPRPQD 910 GFTQWCEQML 920 HTLSATGSLD 930 VPMAVAILKE 940 VESPYDVHDY 950 IRSCLGDTLE 960 AKEFAKQFLE 970 RRAKQKASQQ 980 RQQQQEAWLS 990 SASLQTAFQA 1000 NHSTKLGPGE 1010 GSKAKRRALM 1020 LHSDPSILGY 1030 SLHGSSGEIE SVDDY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0032991	protein-containing complex
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway
Biological Process	GO:0045947	negative regulation of translational initiation
Biological Process	GO:1990261	pre-mRNA catabolic process

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.