Search Results
Overview
| Uniprot ID | O75439 |
|---|---|
| Protein Name | Mitochondrial-processing peptidase subunit beta |
| Gene Name | PMPCB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 472 | IAAVGPIKQLPDFKQ |
Function
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable) (PubMed:29576218). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed:22354088)
Protein Sequence
10
MAAAAARVVL
20
SSAARRRLWG
30
FSESLLIRGA
40
AGRSLYFGEN
50
RLRSTQAATQ
60
VVLNVPETRV
70
TCLESGLRVA
80
SEDSGLSTCT
90
VGLWIDAGSR
100
YENEKNNGTA
110
HFLEHMAFKG
120
TKKRSQLDLE
130
LEIENMGAHL
140
NAYTSREQTV
150
YYAKAFSKDL
160
PRAVEILADI
170
IQNSTLGEAE
180
IERERGVILR
190
EMQEVETNLQ
200
EVVFDYLHAT
210
AYQNTALGRT
220
ILGPTENIKS
230
ISRKDLVDYI
240
TTHYKGPRIV
250
LAAAGGVSHD
260
ELLDLAKFHF
270
GDSLCTHKGE
280
IPALPPCKFT
290
GSEIRVRDDK
300
MPLAHLAIAV
310
EAVGWAHPDT
320
ICLMVANTLI
330
GNWDRSFGGG
340
MNLSSKLAQL
350
TCHGNLCHSF
360
QSFNTSYTDT
370
GLWGLYMVCE
380
SSTVADMLHV
390
VQKEWMRLCT
400
SVTESEVARA
410
RNLLKTNMLL
420
QLDGSTPICE
430
DIGRQMLCYN
440
RRIPIPELEA
450
RIDAVNAETI
460
REVCTKYIYN
470
RSPAIAAVGP
480
IKQLPDFKQI
RSNMCWLRD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0017087 | mitochondrial processing peptidase complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Molecular Function | GO:0009003 | signal peptidase activity |
| Biological Process | GO:0006851 | mitochondrial calcium ion transmembrane transport |
| Biological Process | GO:0016485 | protein processing |
| Biological Process | GO:0006627 | protein processing involved in protein targeting to mitochondrion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.