Search Results

Overview

Uniprot IDO75445
Protein NameUsherin
Gene NameUSH2A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
199 NGLQPPIKVMTLGRI

Function

Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport

Protein Sequence

10 MNCPVLSLGS 20 GFLFQVIEML 30 IFAYFASISL 40 TESRGLFPRL 50 ENVGAFKKVS 60 IVPTQAVCGL 70 PDRSTFCHSS 80 AAAESIQFCT 90 QRFCIQDCPY 100 RSSHPTYTAL 110 FSAGLSSCIT 120 PDKNDLHPNA 130 HSNSASFIFG 140 NHKSCFSSPP 150 SPKLMASFTL 160 AVWLKPEQQG 170 VMCVIEKTVD 180 GQIVFKLTIS 190 EKETMFYYRT 200 VNGLQPPIKV 210 MTLGRILVKK 220 WIHLSVQVHQ 230 TKISFFINGV 240 EKDHTPFNAR 250 TLSGSITDFA 260 SGTVQIGQSL 270 NGLEQFVGRM 280 QDFRLYQVAL 290 TNREILEVFS 300 GDLLRLHAQS 310 HCRCPGSHPR 320 VHPLAQRYCI 330 PNDAGDTADN 340 RVSRLNPEAH 350 PLSFVNDNDV 360 GTSWVSNVFT 370 NITQLNQGVT 380 ISVDLENGQY 390 QVFYIIIQFF 400 SPQPTEIRIQ 410 RKKENSLDWE 420 DWQYFARNCG 430 AFGMKNNGDL 440 EKPDSVNCLQ 450 LSNFTPYSRG 460 NVTFSILTPG 470 PNYRPGYNNF 480 YNTPSLQEFV 490 KATQIRFHFH 500 GQYYTTETAV 510 NLRHRYYAVD 520 EITISGRCQC 530 HGHADNCDTT 540 SQPYRCLCSQ 550 ESFTEGLHCD 560 RCLPLYNDKP 570 FRQGDQVYAF 580 NCKPCQCNSH 590 SKSCHYNISV 600 DPFPFEHFRG 610 GGGVCDDCEH 620 NTTGRNCELC 630 KDYFFRQVGA 640 DPSAIDVCKP 650 CDCDTVGTRN 660 GSILCDQIGG 670 QCNCKRHVSG 680 RQCNQCQNGF 690 YNLQELDPDG 700 CSPCNCNTSG 710 TVDGDITCHQ 720 NSGQCKCKAN 730 VIGLRCDHCN 740 FGFKFLRSFN 750 DVGCEPCQCN 760 LHGSVNKFCN 770 PHSGQCECKK 780 EAKGLQCDTC 790 RENFYGLDVT 800 NCKACDCDTA 810 GSLPGTVCNA 820 KTGQCICKPN 830 VEGRQCNKCL 840 EGNFYLRQNN 850 SFLCLPCNCD 860 KTGTINGSLL 870 CNKSTGQCPC 880 KLGVTGLRCN 890 QCEPHRYNLT 900 IDNFQHCQMC 910 ECDSLGTLPG 920 TICDPISGQC 930 LCVPNRQGRR 940 CNQCQPGFYI 950 SPGNATGCLP 960 CSCHTTGAVN 970 HICNSLTGQC 980 VCQDASIAGQ 990 RCDQCKDHYF 1000 GFDPQTGRCQ 1010 PCNCHLSGAL 1020 NETCHLVTGQ 1030 CFCKQFVTGS 1040 KCDACVPSAS 1050 HLDVNNLLGC 1060 SKTPFQQPPP 1070 RGQVQSSSAI 1080 NLSWSPPDSP 1090 NAHWLTYSLL 1100 RDGFEIYTTE 1110 DQYPYSIQYF 1120 LDTDLLPYTK 1130 YSYYIETTNV 1140 HGSTRSVAVT 1150 YKTKPGVPEG 1160 NLTLSYIIPI 1170 GSDSVTLTWT 1180 TLSNQSGPIE 1190 KYILSCAPLA 1200 GGQPCVSYEG 1210 HETSATIWNL 1220 VPFAKYDFSV 1230 QACTSGGCLH 1240 SLPITVTTAQ 1250 APPQRLSPPK 1260 MQKISSTELH 1270 VEWSPPAELN 1280 GIIIRYELYM 1290 RRLRSTKETT 1300 SEESRVFQSS 1310 GWLSPHSFVE 1320 SANENALKPP 1330 QTMTTITGLE 1340 PYTKYEFRVL 1350 AVNMAGSVSS 1360 AWVSERTGES 1370 APVFMIPPSV 1380 FPLSSYSLNI 1390 SWEKPADNVT 1400 RGKVVGYDIN 1410 MLSEQSPQQS 1420 IPMAFSQLLH 1430 TAKSQELSYT 1440 VEGLKPYRIY 1450 EFTITLCNSV 1460 GCVTSASGAG 1470 QTLAAAPAQL 1480 RPPLVKGINS 1490 TTIHLRWFPP 1500 EELNGPSPIY 1510 QLERRESSLP 1520 ALMTTMMKGI 1530 RFIGNGYCKF 1540 PSSTHPVNTD 1550 FTGIKASFRT 1560 KVPEGLIVFA 1570 ASPGNQEEYF 1580 ALQLKKGRLY 1590 FLFDPQGSPV 1600 EVTTTNDHGK 1610 QYSDGKWHEI 1620 IAIRHQAFGQ 1630 ITLDGIYTGS 1640 SAILNGSTVI 1650 GDNTGVFLGG 1660 LPRSYTILRK 1670 DPEIIQKGFV 1680 GCLKDVHFMK 1690 NYNPSAIWEP 1700 LDWQSSEEQI 1710 NVYNSWEGCP 1720 ASLNEGAQFL 1730 GAGFLELHPY 1740 MFHGGMNFEI 1750 SFKFRTDQLN 1760 GLLLFVYNKD 1770 GPDFLAMELK 1780 SGILTFRLNT 1790 SLAFTQVDLL 1800 LGLSYCNGKW 1810 NKVIIKKEGS 1820 FISASVNGLM 1830 KHASESGDQP 1840 LVVNSPVYVG 1850 GIPQELLNSY 1860 QHLCLEQGFG 1870 GCMKDVKFTR 1880 GAVVNLASVS 1890 SGAVRVNLDG 1900 CLSTDSAVNC 1910 RGNDSILVYQ 1920 GKEQSVYEGG 1930 LQPFTEYLYR 1940 VIASHEGGSV 1950 YSDWSRGRTT 1960 GAAPQSVPTP 1970 SRVRSLNGYS 1980 IEVTWDEPVV 1990 RGVIEKYILK 2000 AYSEDSTRPP 2010 RMPSASAEFV 2020 NTSNLTGILT 2030 GLLPFKNYAV 2040 TLTACTLAGC 2050 TESSHALNIS 2060 TPQEAPQEVQ 2070 PPVAKSLPSS 2080 LLLSWNPPKK 2090 ANGIITQYCL 2100 YMDGRLIYSG 2110 SEENYIVTDL 2120 AVFTPHQFLL 2130 SACTHVGCTN 2140 SSWVLLYTAQ 2150 LPPEHVDSPV 2160 LTVLDSRTIH 2170 IQWKQPRKIS 2180 GILERYVLYM 2190 SNHTHDFTIW 2200 SVIYNSTELF 2210 QDHMLQYVLP 2220 GNKYLIKLGA 2230 CTGGGCTVSE 2240 ASEALTDEDI 2250 PEGVPAPKAH 2260 SYSPDSFNVS 2270 WTEPEYPNGV 2280 ITSYGLYLDG 2290 ILIHNSSELS 2300 YRAYGFAPWS 2310 LHSFRVQACT 2320 AKGCALGPLV 2330 ENRTLEAPPE 2340 GTVNVFVKTQ 2350 GSRKAHVRWE 2360 APFRPNGLLT 2370 HSVLFTGIFY 2380 VDPVGNNYTL 2390 LNVTKVMYSG 2400 EETNLWVLID 2410 GLVPFTNYTV 2420 QVNISNSQGS 2430 LITDPITIAM 2440 PPGAPDGVLP 2450 PRLSSATPTS 2460 LQVVWSTPAR 2470 NNAPGSPRYQ 2480 LQMRSGDSTH 2490 GFLELFSNPS 2500 ASLSYEVSDL 2510 QPYTEYMFRL 2520 VASNGFGSAH 2530 SSWIPFMTAE 2540 DKPGPVVPPI 2550 LLDVKSRMML 2560 VTWQHPRKSN 2570 GVITHYNIYL 2580 HGRLYLRTPG 2590 NVTNCTVMHL 2600 HPYTAYKFQV 2610 EACTSKGCSL 2620 SPESQTVWTL 2630 PGAPEGIPSP 2640 ELFSDTPTSV 2650 IISWQPPTHP 2660 NGLVENFTIE 2670 RRVKGKEEVT 2680 TLVTLPRSHS 2690 MRFIDKTSAL 2700 SPWTKYEYRV 2710 LMSTLHGGTN 2720 SSAWVEVTTR 2730 PSRPAGVQPP 2740 VVTVLEPDAV 2750 QVTWKPPLIQ 2760 NGDILSYEIH 2770 MPDPHITLTN 2780 VTSAVLSQKV 2790 THLIPFTNYS 2800 VTIVACSGGN 2810 GYLGGCTESL 2820 PTYVTTHPTV 2830 PQNVGPLSVI 2840 PLSESYVVIS 2850 WQPPSKPNGP 2860 NLRYELLRRK 2870 IQQPLASNPP 2880 EDLNRWHNIY 2890 SGTQWLYEDK 2900 GLSRFTTYEY 2910 MLFVHNSVGF 2920 TPSREVTVTT 2930 LAGLPERGAN 2940 LTASVLNHTA 2950 IDVRWAKPTV 2960 QDLQGEVEYY 2970 TLFWSSATSN 2980 DSLKILPDVN 2990 SHVIGHLKPN 3000 TEYWIFISVF 3010 NGVHSINSAG 3020 LHATTCDGEP 3030 QGMLPPEVVI 3040 INSTAVRVIW 3050 TSPSNPNGVV 3060 TEYSIYVNNK 3070 LYKTGMNVPG 3080 SFILRDLSPF 3090 TIYDIQVEVC 3100 TIYACVKSNG 3110 TQITTVEDTP 3120 SDIPTPTIRG 3130 ITSRSLQIDW 3140 VSPRKPNGII 3150 LGYDLLWKTW 3160 YPCAKTQKLV 3170 QDQSDELCKA 3180 VRCQKPESIC 3190 GHICYSSEAK 3200 VCCNGVLYNP 3210 KPGHRCCEEK 3220 YIPFVLNSTG 3230 VCCGGRIQEA 3240 QPNHQCCSGY 3250 YARILPGEVC 3260 CPDEQHNRVS 3270 VGIGDSCCGR 3280 MPYSTSGNQI 3290 CCAGRLHDGH 3300 GQKCCGRQIV 3310 SNDLECCGGE 3320 EGVVYNRLPG 3330 MFCCGQDYVN 3340 MSDTICCSAS 3350 SGESKAHIKK 3360 NDPVPVKCCE 3370 TELIPKSQKC 3380 CNGVGYNPLK 3390 YVCSDKISTG 3400 MMMKETKECR 3410 ILCPASMEAT 3420 EHCGRCDFNF 3430 TSHICTVIRG 3440 SHNSTGKASI 3450 EEMCSSAEET 3460 IHTGSVNTYS 3470 YTDVNLKPYM 3480 TYEYRISAWN 3490 SYGRGLSKAV 3500 RARTKEDVPQ 3510 GVSPPTWTKI 3520 DNLEDTIVLN 3530 WRKPIQSNGP 3540 IIYYILLRNG 3550 IERFRGTSLS 3560 FSDKEGIQPF 3570 QEYSYQLKAC 3580 TVAGCATSSK 3590 VVAATTQGVP 3600 ESILPPSITA 3610 LSAVALHLSW 3620 SVPEKSNGVI 3630 KEYQIRQVGK 3640 GLIHTDTTDR 3650 RQHTVTGLQP 3660 YTNYSFTLTA 3670 CTSAGCTSSE 3680 PFLGQTLQAA 3690 PEGVWVTPRH 3700 IIINSTTVEL 3710 YWSLPEKPNG 3720 LVSQYQLSRN 3730 GNLLFLGGSE 3740 EQNFTDKNLE 3750 PNSRYTYKLE 3760 VKTGGGSSAS 3770 DDYIVQTPMS 3780 TPEEIYPPYN 3790 ITVIGPYSIF 3800 VAWIPPGILI 3810 PEIPVEYNVL 3820 LNDGSVTPLA 3830 FSVGHHQSTL 3840 LENLTPFTQY 3850 EIRIQACQNG 3860 SCGVSSRMFV 3870 KTPEAAPMDL 3880 NSPVLKALGS 3890 ACIEIKWMPP 3900 EKPNGIIINY 3910 FIYRRPAGIE 3920 EESVLFVWSE 3930 GALEFMDEGD 3940 TLRPFTLYEY 3950 RVRACNSKGS 3960 VESLWSLTQT 3970 LEAPPQDFPA 3980 PWAQATSAHS 3990 VLLNWTKPES 4000 PNGIISHYRV 4010 VYQERPDDPT 4020 FNSPTVHAFT 4030 VKGTSHQAHL 4040 YGLEPFTTYR 4050 IGVVAANHAG 4060 EILSPWTLIQ 4070 TLESSPSGLR 4080 NFIVEQKENG 4090 RALLLQWSEP 4100 MRTNGVIKTY 4110 NIFSDGFLEY 4120 SGLNRQFLFR 4130 RLDPFTLYTL 4140 TLEACTRAGC 4150 AHSAPQPLWT 4160 DEAPPDSQLA 4170 PTVHSVKSTS 4180 VELSWSEPVN 4190 PNGKIIRYEV 4200 IRRCFEGKAW 4210 GNQTIQADEK 4220 IVFTEYNTER 4230 NTFMYNDTGL 4240 QPWTQCEYKI 4250 YTWNSAGHTC 4260 SSWNVVRTLQ 4270 APPEGLSPPV 4280 ISYVSMNPQK 4290 LLISWIPPEQ 4300 SNGIIQSYRL 4310 QRNEMLYPFS 4320 FDPVTFNYTD 4330 EELLPFSTYS 4340 YALQACTSGG 4350 CSTSKPTSIT 4360 TLEAAPSEVS 4370 PPDLWAVSAT 4380 QMNVCWSPPT 4390 VQNGKITKYL 4400 VRYDNKESLA 4410 GQGLCLLVSH 4420 LQPYSQYNFS 4430 LVACTNGGCT 4440 ASVSKSAWTM 4450 EALPENMDSP 4460 TLQVTGSESI 4470 EITWKPPRNP 4480 NGQIRSYELR 4490 RDGTIVYTGL 4500 ETRYRDFTLT 4510 PGVEYSYTVT 4520 ASNSQGGILS 4530 PLVKDRTSPS 4540 APSGMEPPKL 4550 QARGPQEILV 4560 NWDPPVRTNG 4570 DIINYTLFIR 4580 ELFERETKII 4590 HINTTHNSFG 4600 MQSYIVNQLK 4610 PFHRYEIRIQ 4620 ACTTLGCASS 4630 DWTFIQTPEI 4640 APLMQPPPHL 4650 EVQMAPGGFQ 4660 PTVSLLWTGP 4670 LQPNGKVLYY 4680 ELYRRQIATQ 4690 PRKSNPVLIY 4700 NGSSTSFIDS 4710 ELLPFTEYEY 4720 QVWAVNSAGK 4730 APSSWTWCRT 4740 GPAPPEGLRA 4750 PTFHVISSTQ 4760 AVVNISAPGK 4770 PNGIVSLYRL 4780 FSSSAHGAET 4790 VLSEGMATQQ 4800 TLHGLQAFTN 4810 YSIGVEACTC 4820 FNCCSKGPTA 4830 ELRTHPAPPS 4840 GLSSPQIGTL 4850 ASRTASFRWS 4860 PPMFPNGVIH 4870 SYELQFHVAC 4880 PPDSALPCTP 4890 SQIETKYTGL 4900 GQKASLGGLQ 4910 PYTTYKLRVV 4920 AHNEVGSTAS 4930 EWISFTTQKE 4940 LPQYRAPFSV 4950 DSNLSVVCVN 4960 WSDTFLLNGQ 4970 LKEYVLTDGG 4980 RRVYSGLDTT 4990 LYIPRTADKT 5000 FFFQVICTTD 5010 EGSVKTPLIQ 5020 YDTSTGLGLV 5030 LTTPGKKKGS 5040 RSKSTEFYSE 5050 LWFIVLMAML 5060 GLILLAIFLS 5070 LILQRKIHKE 5080 PYIRERPPLV 5090 PLQKRMSPLN 5100 VYPPGENHMG 5110 LADTKIPRSG 5120 TPVSIRSNRS 5130 ACVLRIPSQN 5140 QTSLTYSQGS 5150 LHRSVSQLMD 5160 IQDKKVLMDN 5170 SLWEAIMGHN 5180 SGLYVDEEDL 5190 MNAIKDFSSV 5200 TKERTTFTDT HL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1990075 periciliary membrane compartment
Cellular Component GO:0002141 stereocilia ankle link
Cellular Component GO:0002142 stereocilia ankle link complex
Cellular Component GO:0032421 stereocilium bundle
Cellular Component GO:0060171 stereocilium membrane
Cellular Component GO:1990696 USH2 complex
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0017022 myosin binding
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0035315 hair cell differentiation
Biological Process GO:0060113 inner ear receptor cell differentiation
Biological Process GO:0048496 maintenance of animal organ identity
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0050953 sensory perception of light stimulus
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0007601 visual perception

Reference

PMID: N/A