Search Results
Overview
| Uniprot ID | O75446 |
|---|---|
| Protein Name | Histone deacetylase complex subunit SAP30 |
| Gene Name | SAP30 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 91 | SFSKRIQKSISQKKV |
Function
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones
Protein Sequence
10
MNGFTPDEMS
20
RGGDAAAAVA
30
AVVAAAAAAA
40
SAGNGTGAGT
50
GAEVPGAGAV
60
SAAGPPGAAG
70
PGPGQLCCLR
80
EDGERCGRAA
90
GNASFSKRIQ
100
KSISQKKVKI
110
ELDKSARHLY
120
ICDYHKNLIQ
130
SVRNRRKRKG
140
SDDDGGDSPV
150
QDIDTPEVDL
160
YQLQVNTLRR
170
YKRHFKLPTR
180
PGLNKAQLVE
190
IVGCHFRSIP
200
VNEKDTLTYF
210
IYSVKNDKNK
220
SDLKVDSGVH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:1902455 | negative regulation of stem cell population maintenance |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:1902459 | positive regulation of stem cell population maintenance |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.