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Overview

Uniprot IDO75448
Protein NameMediator of RNA polymerase II transcription subunit 24
Gene NameMED24
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
384 SVNNLMAKRKADREH

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Protein Sequence

10 MKVVNLKQAI 20 LQAWKERWSD 30 YQWAINMKKF 40 FPKGATWDIL 50 NLADALLEQA 60 MIGPSPNPLI 70 LSYLKYAISS 80 QMVSYSSVLT 90 AISKFDDFSR 100 DLCVQALLDI 110 MDMFCDRLSC 120 HGKAEECIGL 130 CRALLSALHW 140 LLRCTAASAE 150 RLREGLEAGT 160 PAAGEKQLAM 170 CLQRLEKTLS 180 STKNRALLHI 190 AKLEEASSWT 200 AIEHSLLKLG 210 EILANLSNPQ 220 LRSQAEQCGT 230 LIRSIPTMLS 240 VHAEQMHKTG 250 FPTVHAVILL 260 EGTMNLTGET 270 QSLVEQLTMV 280 KRMQHIPTPL 290 FVLEIWKACF 300 VGLIESPEGT 310 EELKWTAFTF 320 LKIPQVLVKL 330 KKYSHGDKDF 340 TEDVNCAFEF 350 LLKLTPLLDK 360 ADQRCNCDCT 370 NFLLQECGKQ 380 GLLSEASVNN 390 LMAKRKADRE 400 HAPQQKSGEN 410 ANIQPNIQLI 420 LRAEPTVTNI 430 LKTMDADHSK 440 SPEGLLGVLG 450 HMLSGKSLDL 460 LLAAAAATGK 470 LKSFARKFIN 480 LNEFTTYGSE 490 ESTKPASVRA 500 LLFDISFLML 510 CHVAQTYGSE 520 VILSESRTGA 530 EVPFFETWMQ 540 TCMPEEGKIL 550 NPDHPCFRPD 560 STKVESLVAL 570 LNNSSEMKLV 580 QMKWHEACLS 590 ISAAILEILN 600 AWENGVLAFE 610 SIQKITDNIK 620 GKVCSLAVCA 630 VAWLVAHVRM 640 LGLDEREKSL 650 QMIRQLAGPL 660 FSENTLQFYN 670 ERVVIMNSIL 680 ERMCADVLQQ 690 TATQIKFPST 700 GVDTMPYWNL 710 LPPKRPIKEV 720 LTDIFAKVLE 730 KGWVDSRSIH 740 IFDTLLHMGG 750 VYWFCNNLIK 760 ELLKETRKEH 770 TLRAVELLYS 780 IFCLDMQQVT 790 LVLLGHILPG 800 LLTDSSKWHS 810 LMDPPGTALA 820 KLAVWCALSS 830 YSSHKGQAST 840 RQKKRHREDI 850 EDYISLFPLD 860 DVQPSKLMRL 870 LSSNEDDANI 880 LSSPTDRSMS 890 SSLSASQLHT 900 VNMRDPLNRV 910 LANLFLLISS 920 ILGSRTAGPH 930 TQFVQWFMEE 940 CVDCLEQGGR 950 GSVLQFMPFT 960 TVSELVKVSA 970 MSSPKVVLAI 980 TDLSLPLGRQ VAAKAIAAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0042809 nuclear vitamin D receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.