Search Results
Overview
| Uniprot ID | O75449 |
|---|---|
| Protein Name | Katanin p60 ATPase-containing subunit A1 |
| Gene Name | KATNA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | SSQYSDPKSHGNRPS |
Function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth
Protein Sequence
10
MSLLMISENV
20
KLAREYALLG
30
NYDSAMVYYQ
40
GVLDQMNKYL
50
YSVKDTYLQQ
60
KWQQVWQEIN
70
VEAKHVKDIM
80
KTLESFKLDS
90
TPLKAAQHDL
100
PASEGEVWSM
110
PVPVERRPSP
120
GPRKRQSSQY
130
SDPKSHGNRP
140
STTVRVHRSS
150
AQNVHNDRGK
160
AVRCREKKEQ
170
NKGREEKNKS
180
PAAVTEPETN
190
KFDSTGYDKD
200
LVEALERDII
210
SQNPNVRWDD
220
IADLVEAKKL
230
LKEAVVLPMW
240
MPEFFKGIRR
250
PWKGVLMVGP
260
PGTGKTLLAK
270
AVATECKTTF
280
FNVSSSTLTS
290
KYRGESEKLV
300
RLLFEMARFY
310
SPATIFIDEI
320
DSICSRRGTS
330
EEHEASRRVK
340
AELLVQMDGV
350
GGTSENDDPS
360
KMVMVLAATN
370
FPWDIDEALR
380
RRLEKRIYIP
390
LPSAKGREEL
400
LRISLRELEL
410
ADDVDLASIA
420
ENMEGYSGAD
430
ITNVCRDASL
440
MAMRRRIEGL
450
TPEEIRNLSK
460
EEMHMPTTME
470
DFEMALKKVS
480
KSVSAADIER
490
YEKWIFEFGS
C
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034451 | centriolar satellite |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0008352 | katanin complex |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0097431 | mitotic spindle pole |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0008568 | microtubule severing ATPase activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0051013 | microtubule severing |
Reference
PMID: N/A