Search Results

Overview

Uniprot IDO75452
Protein NameRetinol dehydrogenase 16
Gene NameRDH16
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
210 MIEPGYFKTAVTSKE
216 FKTAVTSKERFLKSF
235 DRSSPEVKEAYGEKF
241 VKEAYGEKFVADYKK
247 EKFVADYKKSAEQME
248 KFVADYKKSAEQMEQ
30 VLSHLRDKYVFITGC
64 LAACLTEKGAEQLRG

Function

Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Also oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:29541409, PubMed:9677409)

Protein Sequence

10 MWLYLAVFVG 20 LYYLLHWYRE 30 RQVLSHLRDK 40 YVFITGCDSG 50 FGKLLARQLD 60 ARGLRVLAAC 70 LTEKGAEQLR 80 GQTSDRLETV 90 TLDVTKTESV 100 AAAAQWVKEC 110 VRDKGLWGLV 120 NNAGISLPTA 130 PNELLTKQDF 140 VTILDVNLLG 150 VIDVTLSLLP 160 LVRRARGRVV 170 NVSSVMGRVS 180 LFGGGYCISK 190 YGVEAFSDSL 200 RRELSYFGVK 210 VAMIEPGYFK 220 TAVTSKERFL 230 KSFLEIWDRS 240 SPEVKEAYGE 250 KFVADYKKSA 260 EQMEQKCTQD 270 LSLVTNCMEH 280 ALIACHPRTR 290 YSAGWDAKLL 300 YLPMSYMPTF 310 LVDAIMYWVS PSPAKAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0043231 intracellular membrane-bounded organelle
Molecular Function GO:0106429 11-cis-retinol dehydrogenase (NAD+) activity
Molecular Function GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
Molecular Function GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
Molecular Function GO:0047023 androsterone dehydrogenase [NAD(P)+] activity
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0008202 steroid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.