Overview
| Uniprot ID | O75461 |
|---|
| Protein Name | Transcription factor E2F6 |
|---|
| Gene Name | E2F6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 100 |
ATKLGVRKRRVYDIT |
| 9 |
SQQRPARKLPSLLLD |
| 95 |
DLNKVATKLGVRKRR |
Function
Inhibitor of E2F-dependent transcription (PubMed:9501179, PubMed:9689056, PubMed:9704927). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9501179, PubMed:9704927). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9501179, PubMed:9689056). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179)
Protein Sequence
10
MSQQRPARKL
20
PSLLLDPTEE
30
TVRRRCRDPI
40
NVEGLLPSKI
50
RINLEDNVQY
60
VSMRKALKVK
70
RPRFDVSLVY
80
LTRKFMDLVR
90
SAPGGILDLN
100
KVATKLGVRK
110
RRVYDITNVL
120
DGIDLVEKKS
130
KNHIRWIGSD
140
LSNFGAVPQQ
150
KKLQEELSDL
160
SAMEDALDEL
170
IKDCAQQLFE
180
LTDDKENERL
190
AYVTYQDIHS
200
IQAFHEQIVI
210
AVKAPAETRL
220
DVPAPREDSI
230
TVHIRSTNGP
240
IDVYLCEVEQ
250
GQTSNKRSEG
260
VGTSSSESTH
270
PEGPEEEENP
280
QQSEELLEVS
N
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0071339 |
MLL1 complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0090575 |
RNA polymerase II transcription regulator complex |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0046983 |
protein dimerization activity |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
PMID: N/A