Search Results

Overview

Uniprot IDO75475
Protein NamePC4 and SFRS1-interacting protein
Gene NamePSIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 ASNEDVTKAVDITTP
143 AVDITTPKAARRGRK
189 RPAATEVKIPKPRGR
201 RGRPKMVKQPCPSES
254 EPDKKEGKKEVESKR
304 AHRRNMLKGQHEKEA
401 TEMITTLKKIRRFKV
407 LKKIRRFKVSQVIME
455 RQHEEANKTKDQGKK
91 IDNNPKVKFSSQQAA

Function

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration

Protein Sequence

10 MTRDFKPGDL 20 IFAKMKGYPH 30 WPARVDEVPD 40 GAVKPPTNKL 50 PIFFFGTHET 60 AFLGPKDIFP 70 YSENKEKYGK 80 PNKRKGFNEG 90 LWEIDNNPKV 100 KFSSQQAATK 110 QSNASSDVEV 120 EEKETSVSKE 130 DTDHEEKASN 140 EDVTKAVDIT 150 TPKAARRGRK 160 RKAEKQVETE 170 EAGVVTTATA 180 SVNLKVSPKR 190 GRPAATEVKI 200 PKPRGRPKMV 210 KQPCPSESDI 220 ITEEDKSKKK 230 GQEEKQPKKQ 240 PKKDEEGQKE 250 EDKPRKEPDK 260 KEGKKEVESK 270 RKNLAKTGVT 280 STSDSEEEGD 290 DQEGEKKRKG 300 GRNFQTAHRR 310 NMLKGQHEKE 320 AADRKRKQEE 330 QMETEQQNKD 340 EGKKPEVKKV 350 EKKRETSMDS 360 RLQRIHAEIK 370 NSLKIDNLDV 380 NRCIEALDEL 390 ASLQVTMQQA 400 QKHTEMITTL 410 KKIRRFKVSQ 420 VIMEKSTMLY 430 NKFKNMFLVG 440 EGDSVITQVL 450 NKSLAEQRQH 460 EEANKTKDQG 470 KKGPNKKLEK 480 EQTGSKTLNG 490 GSDAQDGNQP 500 QHNGESNEDS 510 KDNHEASTKK 520 KPSSEERETE 530 ISLKDSTLDN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0097100 supercoiled DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000395 mRNA 5'-splice site recognition
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0009408 response to heat
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.