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Overview

Uniprot IDO75477
Protein NameErlin-1
Gene NameERLIN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
201 KLLIAAQKQKVVEKE
228 EKIAQVAKIRFQQKV
269 AEYYAAHKYATSNKH
277 YATSNKHKLTPEYLE
287 PEYLELKKYQAIASN

Function

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618)

Protein Sequence

10 MNMTQARVLV 20 AAVVGLVAVL 30 LYASIHKIEE 40 GHLAVYYRGG 50 ALLTSPSGPG 60 YHIMLPFITT 70 FRSVQTTLQT 80 DEVKNVPCGT 90 SGGVMIYIDR 100 IEVVNMLAPY 110 AVFDIVRNYT 120 ADYDKTLIFN 130 KIHHELNQFC 140 SAHTLQEVYI 150 ELFDQIDENL 160 KQALQKDLNL 170 MAPGLTIQAV 180 RVTKPKIPEA 190 IRRNFELMEA 200 EKTKLLIAAQ 210 KQKVVEKEAE 220 TERKKAVIEA 230 EKIAQVAKIR 240 FQQKVMEKET 250 EKRISEIEDA 260 AFLAREKAKA 270 DAEYYAAHKY 280 ATSNKHKLTP 290 EYLELKKYQA 300 IASNSKIYFG 310 SNIPNMFVDS 320 SCALKYSDIR 330 TGRESSLPSK 340 EALEPSGENV IQNKESTG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0015485 cholesterol binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0045541 negative regulation of cholesterol biosynthetic process
Biological Process GO:0045717 negative regulation of fatty acid biosynthetic process
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0032933 SREBP signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.