Overview
| Uniprot ID | O75478 |
|---|
| Protein Name | Transcriptional adapter 2-alpha |
|---|
| Gene Name | TADA2A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 421 |
AQARALIKIDVNKTR |
| 426 |
LIKIDVNKTRKIYDF |
Function
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376)
Protein Sequence
10
MDRLGPFSND
20
PSDKPPCRGC
30
SSYLMEPYIK
40
CAECGPPPFF
50
LCLQCFTRGF
60
EYKKHQSDHT
70
YEIMTSDFPV
80
LDPSWTAQEE
90
MALLEAVMDC
100
GFGNWQDVAN
110
QMCTKTKEEC
120
EKHYMKHFIN
130
NPLFASTLLN
140
LKQAEEAKTA
150
DTAIPFHSTD
160
DPPRPTFDSL
170
LSRDMAGYMP
180
ARADFIEEFD
190
NYAEWDLRDI
200
DFVEDDSDIL
210
HALKMAVVDI
220
YHSRLKERQR
230
RKKIIRDHGL
240
INLRKFQLME
250
RRYPKEVQDL
260
YETMRRFARI
270
VGPVEHDKFI
280
ESHALEFELR
290
REIKRLQEYR
300
TAGITNFCSA
310
RTYDHLKKTR
320
EEERLKRTML
330
SEVLQYIQDS
340
SACQQWLRRQ
350
ADIDSGLSPS
360
IPMASNSGRR
370
SAPPLNLTGL
380
PGTEKLNEKE
390
KELCQMVRLV
400
PGAYLEYKSA
410
LLNECNKQGG
420
LRLAQARALI
430
KIDVNKTRKI
440
YDFLIREGYI
TKG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0140672 |
ATAC complex |
| Cellular Component |
GO:0072686 |
mitotic spindle |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000124 |
SAGA complex |
| Cellular Component |
GO:0070461 |
SAGA-type complex |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0051302 |
regulation of cell division |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0045995 |
regulation of embryonic development |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0090043 |
regulation of tubulin deacetylation |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.