Search Results
Overview
| Uniprot ID | O75489 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| Gene Name | NDUFS3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 259 | LKLEAGDKKPDAK** |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14729820, PubMed:30140060). Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060)
Protein Sequence
10
MAAAAVARLW
20
WRGILGASAL
30
TRGTGRPSVL
40
LLPVRRESAG
50
ADTRPTVRPR
60
NDVAHKQLSA
70
FGEYVAEILP
80
KYVQQVQVSC
90
FNELEVCIHP
100
DGVIPVLTFL
110
RDHTNAQFKS
120
LVDLTAVDVP
130
TRQNRFEIVY
140
NLLSLRFNSR
150
IRVKTYTDEL
160
TPIESAVSVF
170
KAANWYEREI
180
WDMFGVFFAN
190
HPDLRRILTD
200
YGFEGHPFRK
210
DFPLSGYVEL
220
RYDDEVKRVV
230
AEPVELAQEF
240
RKFDLNSPWE
250
AFPVYRQPPE
260
SLKLEAGDKK
PDAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0003954 | NADH dehydrogenase activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:0072593 | reactive oxygen species metabolic process |
| Biological Process | GO:0021762 | substantia nigra development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.