Overview
| Uniprot ID | O75494 |
|---|
| Protein Name | Serine/arginine-rich splicing factor 10 |
|---|
| Gene Name | SRSF10 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 218 |
TDSKTHYKSGSRYEK |
| 97 |
RKTPNQMKAKEGRNV |
Function
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250)
Protein Sequence
10
MSRYLRPPNT
20
SLFVRNVADD
30
TRSEDLRREF
40
GRYGPIVDVY
50
VPLDFYTRRP
60
RGFAYVQFED
70
VRDAEDALHN
80
LDRKWICGRQ
90
IEIQFAQGDR
100
KTPNQMKAKE
110
GRNVYSSSRY
120
DDYDRYRRSR
130
SRSYERRRSR
140
SRSFDYNYRR
150
SYSPRNSRPT
160
GRPRRSRSHS
170
DNDRFKHRNR
180
SFSRSKSNSR
190
SRSKSQPKKE
200
MKAKSRSRSA
210
SHTKTRGTSK
220
TDSKTHYKSG
230
SRYEKESRKK
240
EPPRSKSQSR
250
SQSRSRSKSR
260
SRSWTSPKSS
GH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043679 |
axon terminus |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0050733 |
RS domain binding |
| Molecular Function |
GO:0051082 |
unfolded protein binding |
| Biological Process |
GO:0016482 |
cytosolic transport |
| Biological Process |
GO:0006376 |
mRNA splice site recognition |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0048024 |
regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0000375 |
RNA splicing, via transesterification reactions |
| Biological Process |
GO:0000244 |
spliceosomal tri-snRNP complex assembly |
Reference
PMID: N/A