Search Results

Overview

Uniprot IDO75521
Protein NameEnoyl-CoA delta isomerase 2
Gene NameECI2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 VEPGTDRKSTGFETL
161 MFNRPKKKNAINTEM
177 HEIMRALKAASKDDS
218 GGVEEKAKNNAVLLR
289 CSSYTFPKIMSPAKA
304 TEMLIFGKKLTAGEA
349 PNALRISKEVIRKRE
359 IRKREREKLHAVNAE
41 TAMRASQKDFENSMN
51 ENSMNQVKLLKKDPG
55 NQVKLLKKDPGNEVK
62 KDPGNEVKLKLYALY
64 PGNEVKLKLYALYKQ
70 LKLYALYKQATEGPC
81 EGPCNMPKPGVFDLI
90 GVFDLINKAKWDAWN
92 FDLINKAKWDAWNAL

Function

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates

Protein Sequence

10 MAMAYLAWRL 20 ARRSCPSSLQ 30 VTSFPVVQLH 40 MNRTAMRASQ 50 KDFENSMNQV 60 KLLKKDPGNE 70 VKLKLYALYK 80 QATEGPCNMP 90 KPGVFDLINK 100 AKWDAWNALG 110 SLPKEAARQN 120 YVDLVSSLSP 130 SLESSSQVEP 140 GTDRKSTGFE 150 TLVVTSEDGI 160 TKIMFNRPKK 170 KNAINTEMYH 180 EIMRALKAAS 190 KDDSIITVLT 200 GNGDYYSSGN 210 DLTNFTDIPP 220 GGVEEKAKNN 230 AVLLREFVGC 240 FIDFPKPLIA 250 VVNGPAVGIS 260 VTLLGLFDAV 270 YASDRATFHT 280 PFSHLGQSPE 290 GCSSYTFPKI 300 MSPAKATEML 310 IFGKKLTAGE 320 ACAQGLVTEV 330 FPDSTFQKEV 340 WTRLKAFAKL 350 PPNALRISKE 360 VIRKREREKL 370 HAVNAEECNV 380 LQGRWLSDEC 390 TNAVVNFLSR KSKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity
Molecular Function GO:0000062 fatty-acyl-CoA binding
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0009062 fatty acid catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.