Search Results
Overview
| Uniprot ID | O75528 |
|---|---|
| Protein Name | Transcriptional adapter 3 |
| Gene Name | TADA3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | GPGPGRPKSKNLQPK |
| 124 | GPGRPKSKNLQPKIQ |
| 129 | KSKNLQPKIQEYEFT |
Function
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4
Protein Sequence
10
MSELKDCPLQ
20
FHDFKSVDHL
30
KVCPRYTAVL
40
ARSEDDGIGI
50
EELDTLQLEL
60
ETLLSSASRR
70
LRVLEAETQI
80
LTDWQDKKGD
90
RRFLKLGRDH
100
ELGAPPKHGK
110
PKKQKLEGKA
120
GHGPGPGPGR
130
PKSKNLQPKI
140
QEYEFTDDPI
150
DVPRIPKNDA
160
PNRFWASVEP
170
YCADITSEEV
180
RTLEELLKPP
190
EDEAEHYKIP
200
PLGKHYSQRW
210
AQEDLLEEQK
220
DGARAAAVAD
230
KKKGLMGPLT
240
ELDTKDVDAL
250
LKKSEAQHEQ
260
PEDGCPFGAL
270
TQRLLQALVE
280
ENIISPMEDS
290
PIPDMSGKES
300
GADGASTSPR
310
NQNKPFSVPH
320
TKSLESRIKE
330
ELIAQGLLES
340
EDRPAEDSED
350
EVLAELRKRQ
360
AELKALSAHN
370
RTKKHDLLRL
380
AKEEVSRQEL
390
RQRVRMADNE
400
VMDAFRKIMA
410
ARQKKRTPTK
420
KEKDQAWKTL
430
KERESILKLL
DG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0140672 | ATAC complex |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000124 | SAGA complex |
| Cellular Component | GO:0033276 | transcription factor TFTC complex |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0030520 | estrogen receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0051302 | regulation of cell division |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0043484 | regulation of RNA splicing |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090043 | regulation of tubulin deacetylation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.