Overview
| Uniprot ID | O75530 |
|---|
| Protein Name | Polycomb protein EED |
|---|
| Gene Name | EED |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 19 |
GTDMPAAKKQKLSSD |
| 20 |
TDMPAAKKQKLSSDE |
Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A
Protein Sequence
10
MSEREVSTAP
20
AGTDMPAAKK
30
QKLSSDENSN
40
PDLSGDENDD
50
AVSIESGTNT
60
ERPDTPTNTP
70
NAPGRKSWGK
80
GKWKSKKCKY
90
SFKCVNSLKE
100
DHNQPLFGVQ
110
FNWHSKEGDP
120
LVFATVGSNR
130
VTLYECHSQG
140
EIRLLQSYVD
150
ADADENFYTC
160
AWTYDSNTSH
170
PLLAVAGSRG
180
IIRIINPITM
190
QCIKHYVGHG
200
NAINELKFHP
210
RDPNLLLSVS
220
KDHALRLWNI
230
QTDTLVAIFG
240
GVEGHRDEVL
250
SADYDLLGEK
260
IMSCGMDHSL
270
KLWRINSKRM
280
MNAIKESYDY
290
NPNKTNRPFI
300
SQKIHFPDFS
310
TRDIHRNYVD
320
CVRWLGDLIL
330
SKSCENAIVC
340
WKPGKMEDDI
350
DKIKPSESNV
360
TILGRFDYSQ
370
CDIWYMRFSM
380
DFWQKMLALG
390
NQVGKLYVWD
400
LEVEDPHKAK
410
CTTLTHHKCG
420
AAIRQTSFSR
430
DSSILIAVCD
440
DASIWRWDRL
R
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005677 |
chromatin silencing complex |
| Cellular Component |
GO:0035098 |
ESC/E(Z) complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0045120 |
pronucleus |
| Cellular Component |
GO:0001739 |
sex chromatin |
| Molecular Function |
GO:0008047 |
enzyme activator activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:1990841 |
promoter-specific chromatin binding |
| Molecular Function |
GO:0001222 |
transcription corepressor binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0140718 |
facultative heterochromatin formation |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0021510 |
spinal cord development |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.