Search Results

Overview

Uniprot IDO75554
Protein NameWW domain-binding protein 4
Gene NameWBP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
274 QKEKSIQKQNSLGSN
286 GSNEEKSKTLKKSNP
290 EKSKTLKKSNPYGEW
357 DGVAPVFKKRRTENG
358 GVAPVFKKRRTENGK

Function

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750)

Protein Sequence

10 MADYWKSQPK 20 KFCDYCKCWI 30 ADNRPSVEFH 40 ERGKNHKENV 50 AKRISEIKQK 60 SLDKAKEEEK 70 ASKEFAAMEA 80 AALKAYQEDL 90 KRLGLESEIL 100 EPSITPVTST 110 IPPTSTSNQQ 120 KEKKEKKKRK 130 KDPSKGRWVE 140 GITSEGYHYY 150 YDLISGASQW 160 EKPEGFQGDL 170 KKTAVKTVWV 180 EGLSEDGFTY 190 YYNTETGESR 200 WEKPDDFIPH 210 TSDLPSSKVN 220 ENSLGTLDES 230 KSSDSHSDSD 240 GEQEAEEGGV 250 STETEKPKIK 260 FKEKNKNSDG 270 GSDPETQKEK 280 SIQKQNSLGS 290 NEEKSKTLKK 300 SNPYGEWQEI 310 KQEVESHEEV 320 DLELPSTENE 330 YVSTSEADGG 340 GEPKVVFKEK 350 TVTSLGVMAD 360 GVAPVFKKRR 370 TENGKSRNLR QRGDDQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071011 precatalytic spliceosome
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Molecular Function GO:0070064 proline-rich region binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0045292 mRNA cis splicing, via spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.