Overview
| Uniprot ID | O75575 |
|---|
| Protein Name | DNA-directed RNA polymerase III subunit RPC9 |
|---|
| Gene Name | CRCP |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 34 |
RKESGKNKHSSGQQN |
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370)
Protein Sequence
10
MEVKDANSAL
20
LSNYEVFQLL
30
TDLKEQRKES
40
GKNKHSSGQQ
50
NLNTITYETL
60
KYISKTPCRH
70
QSPEIVREFL
80
TALKSHKLTK
90
AEKLQLLNHR
100
PVTAVEIQLM
110
VEESEERLTE
120
EQIEALLHTV
130
TSILPAEPEA
140
EQKKNTNSNV
AMDEEDPA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0001669 |
acrosomal vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0009360 |
DNA polymerase III complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005666 |
RNA polymerase III complex |
| Molecular Function |
GO:0001635 |
calcitonin gene-related peptide receptor activity |
| Molecular Function |
GO:0003899 |
DNA-directed RNA polymerase activity |
| Molecular Function |
GO:0000166 |
nucleotide binding |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0006386 |
termination of RNA polymerase III transcription |
| Biological Process |
GO:0006383 |
transcription by RNA polymerase III |
| Biological Process |
GO:0006384 |
transcription initiation at RNA polymerase III promoter |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.