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Overview

Uniprot IDO75586
Protein NameMediator of RNA polymerase II transcription subunit 6
Gene NameMED6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
236 VQQTVSAKGPPEKRM
241 SAKGPPEKRMRLQ**

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Protein Sequence

10 MAAVDIRDNL 20 LGISWVDSSW 30 IPILNSGSVL 40 DYFSERSNPF 50 YDRTCNNEVV 60 KMQRLTLEHL 70 NQMVGIEYIL 80 LHAQEPILFI 90 IRKQQRQSPA 100 QVIPLADYYI 110 IAGVIYQAPD 120 LGSVINSRVL 130 TAVHGIQSAF 140 DEAMSYCRYH 150 PSKGYWWHFK 160 DHEEQDKVRP 170 KAKRKEEPSS 180 IFQRQRVDAL 190 LLDLRQKFPP 200 KFVQLKPGEK 210 PVPVDQTKKE 220 AEPIPETVKP 230 EEKETTKNVQ 240 QTVSAKGPPE KRMRLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070847 core mediator complex
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0001223 transcription coactivator binding
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.