Search Results

Overview

Uniprot IDO75592
Protein NameE3 ubiquitin-protein ligase MYCBP2
Gene NameMYCBP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3009 EKSSFLFKGDGSKPL

Function

Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquitination and degradation of NR1D1 (PubMed:20534529)

Protein Sequence

10 MMMCAATASP 20 AAASSGLGGD 30 GFYPAATFSS 40 SPAPGALFMP 50 VPDGSVAAAG 60 LGLGLPAADS 70 RGHYQLLLSG 80 RALADRYRRI 90 YTAALNDRDQ 100 GGGSAGHPAS 110 RNKKILNKKK 120 LKRKQKSKSK 130 VKTRSKSENL 140 ENTVIIPDIK 150 LHSNPSAFNI 160 YCNVRHCVLE 170 WQKKEISLAA 180 ASKNSVQSGE 190 SDSDEEEESK 200 EPPIKLPKII 210 EVGLCEVFEL 220 IKETRFSHPS 230 LCLRSLQALL 240 NVLQGQQPEG 250 LQSEPPEVLE 260 SLFQLLLEIT 270 VRSTGMNDST 280 GQSLTALSCA 290 CLFSLVASWG 300 ETGRTLQAIS 310 AILTNNGSHA 320 CQTIQVPTIL 330 NSLQRSVQAV 340 LVGKIQIQDW 350 FSNGIKKAAL 360 MHKWPLKEIS 370 VDEDDQCLLQ 380 NDGFFLYLLC 390 KDGLYKIGSG 400 YSGTVRGHIY 410 NSTSRIRNRK 420 EKKSWLGYAQ 430 GYLLYRDVNN 440 HSMTAIRISP 450 ETLEQDGTVM 460 LPDCHTEGQN 470 ILFTDGEYIN 480 QIAASRDDGF 490 VVRIFATSTE 500 PVLQQELQLK 510 LARKCLHACG 520 ISLFDLEKDL 530 HIISTGFDEE 540 SAILGAGREF 550 ALMKTANGKI 560 YYTGKYQSLG 570 IKQGGPSAGK 580 WVELPITKSP 590 KIVHFSVGHD 600 GSHALLVAED 610 GSIFFTGSAS 620 KGEDGESTKS 630 RRQSKPYKPK 640 KIIKMEGKIV 650 VYTACNNGSS 660 SVISKDGELY 670 MFGKDAIYSD 680 SSSLVTDLKG 690 HFVTQVAMGK 700 AHTCVLMKNG 710 EVWTFGVNNK 720 GQCGRDTGAM 730 NQGGKGFGVE 740 NMATAMDEDL 750 EEELDEKDEK 760 SMMCPPGMHK 770 WKLEQCMVCT 780 VCGDCTGYGA 790 SCVSSGRPDR 800 VPGGICGCGS 810 GESGCAVCGC 820 CKACARELDG 830 QEARQRGILD 840 AVKEMIPLDL 850 LLAVPVPGVN 860 IEEHLQLRQE 870 EKRQRVIRRH 880 RLEEGRGPLV 890 FAGPIFMNHR 900 EQALARLRSH 910 PAQLKHKRDK 920 HKDGSGERGE 930 KDASKITTYP 940 PGSVRFDCEL 950 RAVQVSCGFH 960 HSVVLMENGD 970 VYTFGYGQHG 980 QLGHGDVNSR 990 GCPTLVQALP 1000 GPSTQVTAGS 1010 NHTAVLLMDG 1020 QVFTFGSFSK 1030 GQLGRPILDV 1040 PYWNAKPAPM 1050 PNIGSKYGRK 1060 ATWIGASGDQ 1070 TFLRIDEALI 1080 NSHVLATSEI 1090 FASKHIIGLV 1100 PASISEPPPF 1110 KCLLINKVDG 1120 SCKTFNDSEQ 1130 EDLQGFGVCL 1140 DPVYDVIWRF 1150 RPNTRELWCY 1160 NAVVADARLP 1170 SAADMQSRCS 1180 ILSPELALPT 1190 GSRALTTRSH 1200 AALHILGCLD 1210 TLAAMQDLKM 1220 GVASTEEETQ 1230 AVMKVYSKED 1240 YSVVNRFESH 1250 GGGWGYSAHS 1260 VEAIRFSADT 1270 DILLGGLGLF 1280 GGRGEYTAKI 1290 KLFELGPDGG 1300 DHETDGDLLA 1310 ETDVLAYDCA 1320 AREKYAMMFD 1330 EPVLLQAGWW 1340 YVAWARVSGP 1350 SSDCGSHGQA 1360 SITTDDGVVF 1370 QFKSSKKSNN 1380 GTDVNAGQIP 1390 QLLYRLPTSD 1400 GSASKGKQQT 1410 SEPVHILKRS 1420 FARTVSVECF 1430 ESLLSILHWS 1440 WTTLVLGVEE 1450 LRGLKGFQFT 1460 ATLLDLERLR 1470 FVGTCCLRLL 1480 RVYTCEIYPV 1490 SATGKAVVEE 1500 TSKLAECIGK 1510 TRTLLRKILS 1520 EGVDHCMVKL 1530 DNDPQGYLSQ 1540 PLSLLEAVLQ 1550 ECHNTFTACF 1560 HSFYPTPALQ 1570 WACLCDLLNC 1580 LDQDIQEANF 1590 KTSSSRLLAA 1600 VMSALCHTSV 1610 KLTSIFPIAY 1620 DGEVLLRSIV 1630 KQVSTENDST 1640 LVHRFPLLVA 1650 HMEKLSQSEE 1660 NISGMTSFRE 1670 VLEKMLVIVV 1680 LPVRNSLRRE 1690 NELFSSHLVS 1700 NTCGLLASIV 1710 SELTASALGS 1720 EVDGLNSLHS 1730 VKASANRFTK 1740 TSQGRSWNTG 1750 NGSPDAICFS 1760 VDKPGIVVVG 1770 FSVYGGGGIH 1780 EYELEVLVDD 1790 SEHAGDSTHS 1800 HRWTSLELVK 1810 GTYTTDDSPS 1820 DIAEIRLDKV 1830 VPLKENVKYA 1840 VRLRNYGSRT 1850 ANGDGGMTTV 1860 QCPDGVTFTF 1870 STCSLSSNGT 1880 NQTRGQIPQI 1890 LYYRSEFDGD 1900 LQSQLLSKAN 1910 EEDKNCSRAL 1920 SVVSTVVRAS 1930 KDLLHRALAV 1940 DADDIPELLS 1950 SSSLFSMLLP 1960 LIIAYIGPVA 1970 AAIPKVAVEV 1980 FGLVQQLLPS 1990 VAILNQKYAP 2000 PAFNPNQSTD 2010 STTGNQPEQG 2020 LSACTTSSHY 2030 AVIESEHPYK 2040 PACVMHYKVT 2050 FPECVRWMTI 2060 EFDPQCGTAQ 2070 SEDVLRLLIP 2080 VRTVQNSGYG 2090 PKLTSVHENL 2100 NSWIELKKFS 2110 GSSGWPTMVL 2120 VLPGNEALFS 2130 LETASDYVKD 2140 DKASFYGFKC 2150 FAIGYEFSPG 2160 PDEGVIQLEK 2170 ELANLGGVCA 2180 AALMKKDLAL 2190 PIGNELEEDL 2200 EILEEAALQV 2210 CKTHSGILGK 2220 GLALSHSPTI 2230 LEALEGNLPL 2240 QIQSNEQSFL 2250 DDFIACVPGS 2260 SGGRLARWLQ 2270 PDSYADPQKT 2280 SLILNKDDIR 2290 CGWPTTITVQ 2300 TKDQYGDVVH 2310 VPNMKVEVKA 2320 VPVSQKKMSL 2330 QQDQAKKPQR 2340 IPGSPAVTAA 2350 SSNTDMTYGG 2360 LASPKLDVSY 2370 EPMIVKEARY 2380 IAITMMKVYE 2390 NYSFEELRFA 2400 SPTPKRPSEN 2410 MLIRVNNDGT 2420 YCANWTPGAI 2430 GLYTLHVTID 2440 GIEIDAGLEV 2450 KVKDPPKGMI 2460 PPGTQLVKPK 2470 SEPQPNKVRK 2480 FVAKDSAGLR 2490 IRSHPSLQSE 2500 QIGIVKVNGT 2510 ITFIDEIHND 2520 DGVWLRLNDE 2530 TIKKYVPNMN 2540 GYTEAWCLSF 2550 NQHLGKSLLV 2560 PVDESKTNTD 2570 DFFKDINSCC 2580 PQEATMQEQD 2590 MPFLRGGPGM 2600 YKVVKTGPSG 2610 HNIRSCPNLR 2620 GIPIGMLVLG 2630 NKVKAVGEVT 2640 NSEGTWVQLD 2650 QNSMVEFCES 2660 DEGEAWSLAR 2670 DRGGNQYLRH 2680 EDEQALLDQN 2690 SQTPPPSPFS 2700 VQAFNKGASC 2710 SAQGFDYGLG 2720 NSKGDRGNIS 2730 TSSKPASTSG 2740 KSELSSKHSR 2750 SLKPDGRMSR 2760 TTADQKKPRG 2770 TESLSASESL 2780 ILKSDAAKLR 2790 SDSHSRSLSP 2800 NHNTLQTLKS 2810 DGRMPSSSRA 2820 ESPGPGSRLS 2830 SPKPKTLPAN 2840 RSSPSGASSP 2850 RSSSPHDKNL 2860 PQKSTAPVKT 2870 KLDPPRERSK 2880 SDSYTLDPDT 2890 LRKKKMPLTE 2900 PLRGRSTSPK 2910 PKSVPKDSTD 2920 SPGSENRAPS 2930 PHVVQENLHS 2940 EVVEVCTSST 2950 LKTNSLTDST 2960 CDDSSEFKSV 2970 DEGSNKVHFS 2980 IGKAPLKDEQ 2990 EMRASPKISR 3000 KCANRHTRPK 3010 KEKSSFLFKG 3020 DGSKPLEPAK 3030 QAMSPSVAEC 3040 ARAVFASFLW 3050 HEGIVHDAMA 3060 CSSFLKFHPE 3070 LSKEHAPIRS 3080 SLNSQQPTEE 3090 KETKLKNRHS 3100 LEISSALNMF 3110 NIAPHGPDIS 3120 KMGSINKNKV 3130 LSMLKEPPLH 3140 EKCEDGKTET 3150 TFEMSMHNTM 3160 KSKSPLPLTL 3170 QHLVAFWEDI 3180 SLATIKAASQ 3190 NMIFPSPGSC 3200 AVLKKKECEK 3210 ENKKSKKEKK 3220 KKEKAEVRPR 3230 GNLFGEMAQL 3240 AVGGPEKDTI 3250 CELCGESHPY 3260 PVTYHMRQAH 3270 PGCGRYAGGQ 3280 GYNSIGHFCG 3290 GWAGNCGDGG 3300 IGGSTWYLVC 3310 DRCREKYLRE 3320 KQAAAREKVK 3330 QSRRKPMQVK 3340 TPRALPTMEA 3350 HQVIKANALF 3360 LLSLSSAAEP 3370 SILCYHPAKP 3380 FQSQLPSVKE 3390 GISEDLPVKM 3400 PCLYLQTLAR 3410 HHHENFVGYQ 3420 DDNLFQDEMR 3430 YLRSTSVPAP 3440 YISVTPDASP 3450 NVFEEPESNM 3460 KSMPPSLETS 3470 PITDTDLAKR 3480 TVFQRSYSVV 3490 ASEYDKQHSI 3500 LPARVKAIPR 3510 RRVNSGDTEV 3520 GSSLLRHPSP 3530 ELSRLISAHS 3540 SLSKGERNFQ 3550 WPVLAFVIQH 3560 HDLEGLEIAM 3570 KQALRKSACR 3580 VFAMEAFNWL 3590 LCNVIQTTSL 3600 HDILWHFVAS 3610 LTPAPVEPEE 3620 EEDEENKTSK 3630 ENSEQEKDTR 3640 VCEHPLSDIV 3650 IAGEAAHPLP 3660 HTFHRLLQTI 3670 SDLMMSLPSG 3680 SSLQQMALRC 3690 WSLKFKQSDH 3700 QFLHQSNVFH 3710 HINNILSKSD 3720 DGDSEESFSI 3730 SIQSGFEAMS 3740 QELCIVMCLK 3750 DLTSIVDIKT 3760 SSRPAMIGSL 3770 TDGSTETFWE 3780 SGDEDKNKTK 3790 NITINCVKGI 3800 NARYVSVHVD 3810 NSRDLGNKVT 3820 SMTFLTGKAV 3830 EDLCRIKQVD 3840 LDSRHIGWVT 3850 SELPGGDNHI 3860 IKIELKGPEN 3870 TLRVRQVKVL 3880 GWKDGESTKI 3890 AGQISASVAQ 3900 QRNCEAETLR 3910 VFRLITSQVF 3920 GKLISGDAEP 3930 TPEQEEKALL 3940 SSPEGEEKVY 3950 NATSDADLKE 3960 HMVGIIFSRS 3970 KLTNLQKQVC 3980 AHIVQAIRME 3990 ATRVREEWEH 4000 AISSKENANS 4010 QPNDEDASSD 4020 AYCFELLSMV 4030 LALSGSNVGR 4040 QYLAQQLTLL 4050 QDLFSLLHTA 4060 SPRVQRQVTS 4070 LLRRVLPEVT 4080 PSRLASIIGV 4090 KSLPPADISD 4100 IIHSTEKGDW 4110 NKLGILDMFL 4120 GCIAKALTVQ 4130 LKAKGTTITG 4140 TAGTTVGKGV 4150 TTVTLPMIFN 4160 SSYLRRGESH 4170 WWMKGSTPTQ 4180 ISEIIIKLIK 4190 DMAAGHLSEA 4200 WSRVTKNAIA 4210 ETIIALTKME 4220 EEFRSPVRCI 4230 ATTRLWLALA 4240 SLCVLDQDHV 4250 DRLSSGRWMG 4260 KDGQQKQMPM 4270 CDNHDDGETA 4280 AIILCNVCGN 4290 LCTDCDRFLH 4300 LHRRTKTHQR 4310 QVFKEEEEAI 4320 KVDLHEGCGR 4330 TKLFWLMALA 4340 DSKTMKAMVE 4350 FREHTGKPTT 4360 SSSEACRFCG 4370 SRSGTELSAV 4380 GSVCSDADCQ 4390 EYAKIACSKT 4400 HPCGHPCGGV 4410 KNEEHCLPCL 4420 HGCDKSATSL 4430 KQDADDMCMI 4440 CFTEALSAAP 4450 AIQLDCSHIF 4460 HLQCCRRVLE 4470 NRWLGPRITF 4480 GFISCPICKN 4490 KINHIVLKDL 4500 LDPIKELYED 4510 VRRKALMRLE 4520 YEGLHKSEAI 4530 TTPGVRFYND 4540 PAGYAMNRYA 4550 YYVCYKCRKA 4560 YFGGEARCDA 4570 EAGRGDDYDP 4580 RELICGACSD 4590 VSRAQMCPKH 4600 GTDFLEYKCR 4610 YCCSVAVFFC 4620 FGTTHFCNAC 4630 HDDFQRMTSI 4640 PKEELPHCPA 4650 GPKGKQLEGT 4660 ECPLHVVHPP 4670 TGEEFALGCG VCRNAHTF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007411 axon guidance
Biological Process GO:0021952 central nervous system projection neuron axonogenesis
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0050905 neuromuscular process
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:1902667 regulation of axon guidance
Biological Process GO:0008582 regulation of synaptic assembly at neuromuscular junction
Biological Process GO:0051124 synaptic assembly at neuromuscular junction

Reference

PMID: N/A