Search Results
Overview
| Uniprot ID | O75600 |
|---|---|
| Protein Name | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial |
| Gene Name | GCAT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 193 | AKLQEAQKHRLRLVA |
Function
Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA
Protein Sequence
10
MWPGNAWRAA
20
LFWVPRGRRA
30
QSALAQLRGI
40
LEGELEGIRG
50
AGTWKSERVI
60
TSRQGPHIRV
70
DGVSGGILNF
80
CANNYLGLSS
90
HPEVIQAGLQ
100
ALEEFGAGLS
110
SVRFICGTQS
120
IHKNLEAKIA
130
RFHQREDAIL
140
YPSCYDANAG
150
LFEALLTPED
160
AVLSDELNHA
170
SIIDGIRLCK
180
AHKYRYRHLD
190
MADLEAKLQE
200
AQKHRLRLVA
210
TDGAFSMDGD
220
IAPLQEICCL
230
ASRYGALVFM
240
DECHATGFLG
250
PTGRGTDELL
260
GVMDQVTIIN
270
STLGKALGGA
280
SGGYTTGPGP
290
LVSLLRQRAR
300
PYLFSNSLPP
310
AVVGCASKAL
320
DLLMGSNTIV
330
QSMAAKTQRF
340
RSKMEAAGFT
350
ISGASHPICP
360
VMLGDARLAS
370
RMADDMLKRG
380
IFVIGFSYPV
390
VPKGKARIRV
400
QISAVHSEED
410
IDRCVEAFVE
VGRLHGALP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006567 | L-threonine catabolic process |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008890 | glycine C-acetyltransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0006520 | amino acid metabolic process |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.