Overview
| Uniprot ID | O75663 |
|---|
| Protein Name | TIP41-like protein |
|---|
| Gene Name | TIPRL |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 29 |
ASKTHIMKSADVEKL |
Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair
Protein Sequence
10
MMIHGFQSSH
20
RDFCFGPWKL
30
TASKTHIMKS
40
ADVEKLADEL
50
HMPSLPEMMF
60
GDNVLRIQHG
70
SGFGIEFNAT
80
DALRCVNNYQ
90
GMLKVACAEE
100
WQESRTEGEH
110
SKEVIKPYDW
120
TYTTDYKGTL
130
LGESLKLKVV
140
PTTDHIDTEK
150
LKAREQIKFF
160
EEVLLFEDEL
170
HDHGVSSLSV
180
KIRVMPSSFF
190
LLLRFFLRID
200
GVLIRMNDTR
210
LYHEADKTYM
220
LREYTSRESK
230
ISSLMHVPPS
240
LFTEPNEISQ
250
YLPIKEAVCE
260
KLIFPERIDP
270
NPADSQKSTQ
VE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0072542 |
protein phosphatase activator activity |
| Molecular Function |
GO:0004864 |
protein phosphatase inhibitor activity |
| Biological Process |
GO:0000077 |
DNA damage checkpoint signaling |
| Biological Process |
GO:0031929 |
TOR signaling |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.