Search Results
Overview
| Uniprot ID | O75674 |
|---|---|
| Protein Name | TOM1-like protein 1 |
| Gene Name | TOM1L1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MAFGKSHRDPYA |
Function
Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity)
Protein Sequence
10
MAFGKSHRDP
20
YATSVGHLIE
30
KATFAGVQTE
40
DWGQFMHICD
50
IINTTQDGPK
60
DAVKALKKRI
70
SKNYNHKEIQ
80
LTLSLIDMCV
90
QNCGPSFQSL
100
IVKKEFVKEN
110
LVKLLNPRYN
120
LPLDIQNRIL
130
NFIKTWSQGF
140
PGGVDVSEVK
150
EVYLDLVKKG
160
VQFPPSEAEA
170
ETARQETAQI
180
SSNPPTSVPT
190
APALSSVIAP
200
KNSTVTLVPE
210
QIGKLHSELD
220
MVKMNVRVMS
230
AILMENTPGS
240
ENHEDIELLQ
250
KLYKTGREMQ
260
ERIMDLLVVV
270
ENEDVTVELI
280
QVNEDLNNAI
290
LGYERFTRNQ
300
QRILEQNKNQ
310
KEATNTTSEP
320
SAPSQDLLDL
330
SPSPRMPRAT
340
LGELNTMNNQ
350
LSGLNFSLPS
360
SDVTNNLKPS
370
LHPQMNLLAL
380
ENTEIPPFAQ
390
RTSQNLTSSH
400
AYDNFLEHSN
410
SVFLQPVSLQ
420
TIAAAPSNQS
430
LPPLPSNHPA
440
MTKSDLQPPN
450
YYEVMEFDPL
460
APAVTTEAIY
470
EEIDAHQHKG
AQNDGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005795 | Golgi stack |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0030295 | protein kinase activator activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Biological Process | GO:0032147 | activation of protein kinase activity |
| Biological Process | GO:0045839 | negative regulation of mitotic nuclear division |
| Biological Process | GO:0031954 | positive regulation of protein autophosphorylation |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.