Search Results
Overview
| Uniprot ID | O75688 |
|---|---|
| Protein Name | Protein phosphatase 1B |
| Gene Name | PPM1B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 90 | EDFRAAGKSGSALEL |
Function
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
Protein Sequence
10
MGAFLDKPKT
20
EKHNAHGAGN
30
GLRYGLSSMQ
40
GWRVEMEDAH
50
TAVVGIPHGL
60
EDWSFFAVYD
70
GHAGSRVANY
80
CSTHLLEHIT
90
TNEDFRAAGK
100
SGSALELSVE
110
NVKNGIRTGF
120
LKIDEYMRNF
130
SDLRNGMDRS
140
GSTAVGVMIS
150
PKHIYFINCG
160
DSRAVLYRNG
170
QVCFSTQDHK
180
PCNPREKERI
190
QNAGGSVMIQ
200
RVNGSLAVSR
210
ALGDYDYKCV
220
DGKGPTEQLV
230
SPEPEVYEIL
240
RAEEDEFIIL
250
ACDGIWDVMS
260
NEELCEYVKS
270
RLEVSDDLEN
280
VCNWVVDTCL
290
HKGSRDNMSI
300
VLVCFSNAPK
310
VSDEAVKKDS
320
ELDKHLESRV
330
EEIMEKSGEE
340
GMPDLAHVMR
350
ILSAENIPNL
360
PPGGGLAGKR
370
NVIEAVYSRL
380
NPHRESDGAS
390
DEAEESGSQG
400
KLVEALRQMR
410
INHRGNYRQL
420
LEEMLTSYRL
430
AKVEGEESPA
440
EPAATATSSN
450
SDAGNPVTMQ
460
ESHTESESGL
470
AELDSSNEDA
GTKMSGEKI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0006499 | N-terminal protein myristoylation |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0050687 | negative regulation of defense response to virus |
| Biological Process | GO:0032688 | negative regulation of interferon-beta production |
| Biological Process | GO:1901223 | negative regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0035970 | peptidyl-threonine dephosphorylation |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0043122 | regulation of canonical NF-kappaB signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.